Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/35,)
Rabbit anti-Human MLLT11 Polyclonal Antibody | anti-MLLT11 antibody
MLLT11 Antibody
Gene Names
MLLT11; AF1Q
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
MLLT11; Polyclonal Antibody; MLLT11 Antibody; AF1Q; anti-MLLT11 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total MLLT11 protein.
Purity/Purification
Antigen Affinity Purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
1.9 mg/ml (varies by lot)
Sequence Length
90
Applicable Applications for anti-MLLT11 antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:25-1:100
Immunogen
Full length fusion protein of human MLLT11
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/35,)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/35,)
Related Product Information for anti-MLLT11 antibody
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1; 11)(q21; q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
Product Categories/Family for anti-MLLT11 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
10,061 Da
NCBI Official Full Name
protein AF1q
NCBI Official Synonym Full Names
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
NCBI Official Symbol
MLLT11
NCBI Official Synonym Symbols
AF1Q
NCBI Protein Information
protein AF1q
UniProt Protein Name
Protein AF1q
Protein Family
UniProt Gene Name
MLLT11
UniProt Synonym Gene Names
AF1Q
UniProt Entry Name
AF1Q_HUMAN
Uniprot Description
MLLT11: a protein that is highly expressed in thymus and leukemic cell lines. A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with MLL.
Protein type: Oncoprotein
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: intracellular
Biological Process: positive regulation of apoptosis; positive regulation of mitochondrial depolarization; positive regulation of transcription, DNA-dependent
Disease: Juvenile Myelomonocytic Leukemia
Similar Products
Product Notes
The MLLT11 mllt11 (Catalog #AAA9415690) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MLLT11 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MLLT11 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the MLLT11 mllt11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLLT11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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