Mouse PTPRN2 Monoclonal Antibody | anti-PTPRN2 antibody

PTPRN2 (Protein Tyrosine Phosphatase, Receptor Type, N Polypeptide 2, IA-2beta, IAR, ICAAR, PTPRP) (PE)

Cat. Num. AAA6186162

• Gene Names: PTPRN2; IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
• Applications: Western Blot
• Purity: Purified
• Synonyms: PTPRN2; Monoclonal Antibody; PTPRN2 (Protein Tyrosine Phosphatase; Receptor Type; N Polypeptide 2; IA-2beta; IAR; ICAAR; PTPRP) (PE); Protein Tyrosine Phosphatase; PTPRP; anti-PTPRN2 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 1G5
• Specificity: Recognizes PTPRN2.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 1015

• Applicable Applications for anti-PTPRN2 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: PTPRN2 (NP_002838, 108aa-212aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: ELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGPRTQL
• Conjugate: PE
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged PTPRN2 is 0.3 ng/ml as a capture antibody.)

Related Product Information for anti-PTPRN2 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]

Product Categories/Family for anti-PTPRN2 antibody

Antibodies; Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 194097440
• NCBI GeneID: 5799
• NCBI Accession #: NP_002838
• NCBI GenBank Nucleotide #: NP_002838.2
• UniProt Accession #: Q92932
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase N2 isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase receptor type N2
• NCBI Official Symbol: PTPRN2
• NCBI Official Synonym Symbols: IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase N2
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase N2
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRN2
• UniProt Synonym Gene Names: KIAA0387; R-PTP-N2; IAR; ICAAR
• UniProt Entry Name: PTPR2_HUMAN

NCBI Description

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]