Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant PTPN1 protein (Right) or empty vector (Left) detected with PTPN1 antibody)
Mouse PTPN1 Monoclonal Antibody | anti-PTPN1 antibody
PTPN1 antibody
FC: 1:100
IHC: 1:150
WB: 1:500-2000
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant PTPN1 protein (Right) or empty vector (Left) detected with PTPN1 antibody)
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant PTPN1 protein (Right) or empty vector (Left) detected with PTPN1 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of PTPN1 protein in paraffin embedded Human lymph node tissue using PTPN1 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of PTPN1 protein in paraffin embedded Human lymph node tissue using PTPN1 antibody)
Immunofluorescence (IF)
(Immunofluorescent staining of COS7 cells transiently transfected with recombinant PTPN1 protein using PTPN1 antibody)
Immunofluorescence (IF)
(Immunofluorescent staining of COS7 cells transiently transfected with recombinant PTPN1 protein using PTPN1 antibody)
NCBI and Uniprot Product Information
Uniprot Description
PTP1B: a non-receptor phospho-tyrosine protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation and inactivation of PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. Negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor. Also reported to dephosphorylate integrin, epidermal growth factor receptor, JAK2 and TYK2, regulating cell growth control and the cellular response to interferon. May regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes.
Protein type: Motility/polarity/chemotaxis; Phosphatase; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Cellular Component: membrane; endoplasmic reticulum; early endosome; plasma membrane; cytoplasmic vesicle; cytosol
Molecular Function: enzyme binding; ephrin receptor binding; protein phosphatase 2A binding; hydrolase activity; zinc ion binding; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; phosphoprotein phosphatase activity; protein kinase binding; insulin receptor binding
Biological Process: regulation of insulin receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; dephosphorylation; unfolded protein response; actin cytoskeleton reorganization; regulation of endocytosis; insulin receptor signaling pathway; regulation of signal transduction; protein amino acid dephosphorylation
Research Articles on PTPN1
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Product Notes
The PTPN1 ptpn1 (Catalog #AAA838794) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PTPN1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). IF: 1:100 FC: 1:100 IHC: 1:150 WB: 1:500-2000. Researchers should empirically determine the suitability of the PTPN1 ptpn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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