Rabbit anti-Human Psoriasin/S100A7 Monoclonal Antibody | anti-S100A7 antibody

Recombinant Anti-Psoriasin/S100A7 Antibody (FITC), Rabbit Monoclonal

Cat. Num. AAA8104938

• Gene Names: S100A7; PSOR1; S100A7c
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A
• Synonyms: Psoriasin/S100A7; Monoclonal Antibody; Recombinant Anti-Psoriasin/S100A7 Antibody (FITC); Rabbit Monoclonal; S100A7 Antibody (FITC); Rabbit MAb; S100 calcium binding protein A7; Anti-PSOR1 Antibody; Anti-S100A7c Antibody; anti-S100A7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 128
• Specificity: Human S100A7
• Purity/Purification: Protein A
• Form/Format: Liquid; Aqueous solution containing 0.5% BSA and 0.09% sodium azide
• Concentration: 10ul/Test, 0.1mg/ml (varies by lot)

• Applicable Applications for anti-S100A7 antibody: Flow Cytometry (FC/FACS/FCM)
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human S100A7 protein
• Conjugation: FITC
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human S100A7 (rh S100A7) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Related Product Information for anti-S100A7 antibody

Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.

Product Categories/Family for anti-S100A7 antibody

Calcium-binding Proteins and Related Molecules

References

Miyasaki, KT. et al., 1993, J. Dent. Res. 72: 517-23. Watson, PH. et al., 1998, Int J Biochem Cell Biol 30 (5):567-71. Emberley, ED. et al., 2004, Breast Cancer Res 6 (4): 153-9. Ohuchida, K. et al., 2006, Clin Cancer Res 12 (18):5417-22. Kouno, T. et al., 2008, J Pept Sci. 14 (10):1129-38. Leon, R. et al., 2009, Biochemistry. 48 (44): 10591-600.

NCBI and Uniprot Product Information

• NCBI GI #: 115298657
• NCBI GeneID: 6278
• NCBI Accession #: NP_002954.2
• NCBI GenBank Nucleotide #: NM_002963.3
• UniProt Accession #: P31151; Q5SY67; Q6FGE3; Q9H1E2
• NCBI Official Full Name: protein S100-A7
• NCBI Official Synonym Full Names: S100 calcium binding protein A7
• NCBI Official Symbol: S100A7
• NCBI Official Synonym Symbols: PSOR1; S100A7c
• NCBI Protein Information: protein S100-A7; S100 calcium-binding protein A7 (psoriasin 1)
• UniProt Protein Name: Protein S100-A7
• Protein Family: Protein
• UniProt Gene Name: S100A7
• UniProt Synonym Gene Names: PSOR1; S100A7C
• UniProt Entry Name: S10A7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

Uniprot Description

S100A7: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; extracellular region; cytosol; nucleus

Molecular Function: RAGE receptor binding; protein binding; zinc ion binding; calcium ion binding

Biological Process: keratinocyte differentiation; sequestering of metal ion; epidermis development; response to reactive oxygen species; innate immune response; response to lipopolysaccharide; angiogenesis; defense response to Gram-negative bacterium