Psoriasin/S100A7 Recombinant Protein | S100A7 recombinant protein

Psoriasin/S100A7 Protein, Human, Recombinant

Cat. Num. AAA8120697

• Gene Names: S100A7; PSOR1; S100A7c
• Purity: >98% as determined by SDS-PAGE
• Synonyms: Psoriasin/S100A7; Psoriasin/S100A7 Protein; Human; Recombinant; Human S100A7/PSOR1 Protein; PSOR1 Protein; S100A7c Protein; S100 calcium binding protein A7; S100A7 recombinant protein

• Host: E Coli
• Purity/Purification: >98% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gln101

• Species: Human
• Predicted N Terminal: Met
• Tag: Native
• Protein Construction: A DNA sequence encoding the native human S100A7 (NP_002954.2)(Met 1-Gln 101) was expressed.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for S100A7 recombinant protein

Background: Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.

Product Categories/Family for S100A7 recombinant protein

Calcium-binding Proteins and Related Molecules

References

Miyasaki, KT. et al., 1993, J. Dent. Res. 72: 517-23. Watson, PH. et al., 1998, Int J Biochem Cell Biol 30 (5):567-71. Emberley, ED. et al., 2004, Breast Cancer Res 6 (4): 153-9. Ohuchida, K. et al., 2006, Clin Cancer Res 12 (18):5417-22. Kouno, T. et al., 2008, J Pept Sci. 14 (10):1129-38. Lea³n, R. et al., 2009, Biochemistry. 48 (44): 10591-600.

NCBI and Uniprot Product Information

• NCBI GI #: 115298657
• NCBI GeneID: 6278
• NCBI Accession #: NP_002954.2
• NCBI GenBank Nucleotide #: NM_002963.3
• UniProt Accession #: P31151; Q5SY67; Q6FGE3; Q9H1E2
• NCBI Official Full Name: protein S100-A7
• NCBI Official Synonym Full Names: S100 calcium binding protein A7
• NCBI Official Symbol: S100A7
• NCBI Official Synonym Symbols: PSOR1; S100A7c
• NCBI Protein Information: protein S100-A7; S100 calcium-binding protein A7 (psoriasin 1)
• UniProt Protein Name: Protein S100-A7
• Protein Family: Protein
• UniProt Gene Name: S100A7
• UniProt Synonym Gene Names: PSOR1; S100A7C
• UniProt Entry Name: S10A7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

Uniprot Description

S100A7: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; extracellular region; cytosol; nucleus

Molecular Function: RAGE receptor binding; protein binding; zinc ion binding; calcium ion binding

Biological Process: keratinocyte differentiation; sequestering of metal ion; epidermis development; response to reactive oxygen species; innate immune response; response to lipopolysaccharide; angiogenesis; defense response to Gram-negative bacterium