Mouse anti-Human Prostate Mucin Antigen Monoclonal Antibody | anti-PLEKHM1 antibody

Prostate Mucin Antigen (PMA)

Cat. Num. AAA603333

• Gene Names: PLEKHM1; B2; AP162; OPTB6
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Prostate Mucin Antigen; Monoclonal Antibody; Prostate Mucin Antigen (PMA); Anti -Prostate Mucin Antigen (PMA); anti-PLEKHM1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 3H257
• Specificity: Human prostate mucin antigen (PMA) Does not react with fetal or benign prostate specimens, nonprostate carcinomas and normal human tissues.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Lyophilized from 0.01M PBS, pH 7.2.

• Applicable Applications for anti-PLEKHM1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Suitable for use in ELISA, Immunoperoxidase staining, Immunofluorescence and Western Blot.
• Immunogen: Membrane protein extracted from human prostate mucin tissues.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-PLEKHM1 antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 160419247
• NCBI GeneID: 9842
• UniProt Accession #: Q9Y4G2; Q6P2R5; Q8TEL9; Q9NPP5; Q9NYA0
• Molecular Weight: 117,443 Da
• NCBI Official Full Name: Pleckstrin homology domain-containing family M member 1
• NCBI Official Synonym Full Names: pleckstrin homology domain containing, family M (with RUN domain) member 1
• NCBI Official Symbol: PLEKHM1
• NCBI Official Synonym Symbols: B2; AP162; OPTB6
• NCBI Protein Information: pleckstrin homology domain-containing family M member 1; 162 kDa adapter protein; PH domain-containing family M member 1
• UniProt Protein Name: Pleckstrin homology domain-containing family M member 1
• Protein Family: Pleckstrin homology domain-containing family
• UniProt Gene Name: PLEKHM1
• UniProt Synonym Gene Names: KIAA0356; PH domain-containing family M member 1; AP162
• UniProt Entry Name: PKHM1_HUMAN

NCBI Description

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

PLEKHM1: Involved in vesicular transport in the osteoclast. May have a role in sialyl-lex-mediated transduction of apoptotic signals. Defects in PLEKHM1 are the cause of osteopetrosis autosomal recessive type 6 (OPTB6); also known as autosomal recessive osteopetrosis intermediate form. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cytoplasm

Molecular Function: metal ion binding

Disease: Osteopetrosis, Autosomal Recessive 6