Prostacyclin Monoclonal Antibody | anti-PTGIS antibody
Anti-Prostacyclin Synthase,Monoclonal
Immunoprecipitate PGI synthase activity(1/2 dilution)
Immunohistochemical localization of PGI2 Synthase (undiluted).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Description
PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family.
Protein type: Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus
Molecular Function: protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity
Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process
Disease: Hypertension, Essential
Research Articles on PTGIS
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Product Notes
The PTGIS ptgis (Catalog #AAA480012) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Prostacyclin can be used in a range of immunoassay formats including, but not limited to, Immunoassay, Immunoprecipitation (IP), Immunohistochemistry (IHC). Immunoassay (titre from 1/10) Immunoprecipitate PGI synthase activity(1/2 dilution) Immunohistochemical localization of PGI2 Synthase (undiluted). Researchers should empirically determine the suitability of the PTGIS ptgis for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Prostacyclin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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