Immunohistochemistry (IHC)
(Prion Protein MBS641931 staining pattern/morphology in normal brain. Tissue was pretreated with Citrate, pH 6.0. A previous lot of this antibody was diluted to 1:500, using IHC-Select® Detection with HRP- DAB. Immunoreactivity is seen predominantly as cell body staining of neurons.)
Mouse Prion Protein Monoclonal Antibody | anti-PrP antibody
Prion Protein, aa109-112 (PrP, CD230) (MaxLight 490)
Gene Names
PRNP; CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
Reactivity
Feline, Hamster, Human
Applications
Immunohistochemistry, Immunoprecipitation, Western Blot
Purity
Purified by Protein A Affinity Chromatography
Synonyms
Prion Protein; Monoclonal Antibody; aa109-112 (PrP; CD230) (MaxLight 490); anti-PrP antibody
Host
Mouse
Reactivity
Feline, Hamster, Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2Q126
Specificity
Recognizes Prion protein, aa109-112. Recognizes native and denatured forms of PrP. Recognizes both protease sensitive and protease resistant forms of PrP (after denatured). Species Crossreactivity: Human, hamster and feline. Does not react with PrP from any other mammalian species.
Purity/Purification
Purified by Protein A Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Applicable Applications for anti-PrP antibody
FLISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Immunogen
Synthetic peptide corresponding to aa109-112 of human prion protein.
Conjugate
MaxLight490
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Immunohistochemistry (IHC)
(Prion Protein MBS641931 staining pattern/morphology in normal brain. Tissue was pretreated with Citrate, pH 6.0. A previous lot of this antibody was diluted to 1:500, using IHC-Select® Detection with HRP- DAB. Immunoreactivity is seen predominantly as cell body staining of neurons.)
Immunohistochemistry (IHC)
(Prion Protein MBS641931 staining pattern/morphology in normal brain. Tissue was pretreated with Citrate, pH 6.0. A previous lot of this antibody was diluted to 1:500, using IHC-Select® Detection with HRP- DAB. Immunoreactivity is seen predominantly as cell body staining of neurons.)
Product Categories/Family for anti-PrP antibody
References
1. Kitamoto, T., et al., Lab Invest. 57: 230-236 (1987). 2. Kascsak, et al.,, J. Virol. 61: 3688-3693 (1987). 3. Kitamoto, T., et al., J. Virol. 65: 6292-6295 (1991). 4. Kascsak, et al., Dev. Biol. Stand. 80: 141-151 (1993). 5. Kascsak, R.J., et al., 26(1-2): 259-268 (1997). 6. Safar, J., et al., Nat. Med. 4(10): 1157-1165 (1998). 7. Rubenstein, R., et al., J. Neurovirol. 5(4): 401-413 (1999). 8. Aucouturier, P., et al., Neurosci. Letter 274(1): 33-36. (1999). 9. Lee, D.C., et al., J. Virol. Methods 84(1): 77-89 (2000). 10. Soto, C., et al., Lancet 355(9199): 192-197 (2000). 11. Carp, R.I., et al., J. Neurovirol. 6(2): 137-144 (2000).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33kDa
NCBI Official Full Name
major prion protein preproprotein
NCBI Official Synonym Full Names
prion protein
NCBI Official Symbol
PRNP
NCBI Official Synonym Symbols
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
NCBI Protein Information
alternative prion protein; major prion protein; CD230 antigen; prion-related protein
UniProt Protein Name
Major prion protein
UniProt Gene Name
PRNP
UniProt Synonym Gene Names
PRIP; PRP; PrP
UniProt Entry Name
PRIO_HUMAN
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Product Notes
The PrP prnp (Catalog #AAA6245512) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Prion Protein, aa109-112 (PrP, CD230) (MaxLight 490) reacts with Feline, Hamster, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Prion Protein can be used in a range of immunoassay formats including, but not limited to, FLISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the PrP prnp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Prion Protein, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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