Mouse anti-Human Prealbumin Monoclonal Antibody | anti-PALB antibody

Prealbumin (TTR, ATTR, Transthyretin, TBPA, PALB) (PE)

Cat. Num. AAA6159633

• Gene Names: TTR; CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Prealbumin; Monoclonal Antibody; Prealbumin (TTR; ATTR; Transthyretin; TBPA; PALB) (PE); CTS; CTS1; HsT2651; PALB; carpal tunnel syndrome 1; prealbumin; amyloidosis type I; thyroxine-binding prealbumin; anti-PALB antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 4D8
• Specificity: Recognizes human Prealbumin.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 650

• Applicable Applications for anti-PALB antibody: FLISA, Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length recombinant protein corresponding to aa21-147 from human Prealbumin with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
• Conjugate: PE
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot detection against immunogen (39.71kD).)

Western Blot (WB)

(Western Blot analysis of TTR expression in transfected 293T cell line by 131760. Lane 1: TTR transfected lysate(15.9kD). Lane 2: Non-transfected lysate.)

Testing Data

(Detection limit for 131760 is ~1ng/ml as a capture antibody.)

Related Product Information for anti-PALB antibody

Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Product Categories/Family for anti-PALB antibody

Antibodies; Albumin

NCBI and Uniprot Product Information

• NCBI GI #: 18089144
• NCBI GeneID: 7276
• NCBI Official Full Name: Homo sapiens transthyretin, mRNA
• NCBI Official Synonym Full Names: transthyretin
• NCBI Official Symbol: TTR
• NCBI Official Synonym Symbols: CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
• NCBI Protein Information: transthyretin
• Protein Family: Calpain-like protease

NCBI Description

This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]