Mouse Plasminogen Activator Inhibitor Type 1, inhibitory Monoclonal Antibody
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1)
Reactivity
Human, Mouse, Rat
Purity
Affinity PurifiedPurified
Synonyms
Plasminogen Activator Inhibitor Type 1; inhibitory; Monoclonal Antibody; inhibitory (PAI-1); Anti -Plasminogen Activator Inhibitor Type 1; anti-Plasminogen Activator Inhibitor Type 1; inhibitory antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9G249
Specificity
Recognizes human plasminogen activator type-1. Species crossreactivity: mouse, rat
Purity/Purification
Affinity Purified
Purified
Purified
Form/Format
Supplied as a liquid in PBS, 0.1% BSA.
Application Notes
Suitable for use in Immunoassays. Also useful for inhibition of biological activity.
Immunogen
Human PAI-1.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody
Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified.
The epitope of monoclonal antibody MA-55F4C12 is within the stretch of 29 amino acids in PAI-1 (region Glu128-Ala131). Glu128, Val129, Glu130, Arg131 and Lys154 are the major determinants. All five residues act cooperatively in the binding to MA-55F4C12 and constitute the epitope. The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 molecule. The monoclonal antibody is a 'switching' antibody, capable of inducing a non-inhibitory substrate form of PAI-1.
The epitope of monoclonal antibody MA-55F4C12 is within the stretch of 29 amino acids in PAI-1 (region Glu128-Ala131). Glu128, Val129, Glu130, Arg131 and Lys154 are the major determinants. All five residues act cooperatively in the binding to MA-55F4C12 and constitute the epitope. The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 molecule. The monoclonal antibody is a 'switching' antibody, capable of inducing a non-inhibitory substrate form of PAI-1.
Product Categories/Family for anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
plasminogen activator inhibitor type 1
Similar Products
Product Notes
The Plasminogen Activator Inhibitor Type 1, inhibitory (Catalog #AAA632788) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. Suitable for use in Immunoassays. Also useful for inhibition of biological activity. Researchers should empirically determine the suitability of the Plasminogen Activator Inhibitor Type 1, inhibitory for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Plasminogen Activator Inhibitor Type 1, inhibitory, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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