Mouse Phosphoinositide 3 kinase, p110 gamma Monoclonal Antibody | anti-PIK3R6 antibody

Phosphoinositide 3 kinase, p110 gamma (PI3K)

Cat. Num. AAA607431

• Gene Names: PIK3R6; p84; C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
• Reactivity: Human, Mouse, Rat
• Applications: Immunoprecipitation, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Phosphoinositide 3 kinase; p110 gamma; Monoclonal Antibody; p110 gamma (PI3K); Anti -Phosphoinositide 3 kinase; anti-PIK3R6 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 6D73
• Specificity: Recognizes human PI(3)K gamma (p110g). Does not crossreact with p110a, p110b and p110d. Species Crossreactivity: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in 100mM Tris, pH 8.0, 40% glycerol.

• Applicable Applications for anti-PIK3R6 antibody: Immunoprecipitation (IP), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Immunoprecipitation and Immunocytochemistry.
• Immunogen: Recombinant human full length protein PI(3)Kg (p110g).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-PIK3R6 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 58082081
• NCBI GeneID: 146850
• NCBI Accession #: NP_001010855.1
• NCBI GenBank Nucleotide #: NM_001010855.2
• UniProt Accession #: Q5UE93; Q658R3
• Molecular Weight: 84,258 Da
• NCBI Official Full Name: phosphoinositide 3-kinase regulatory subunit 6
• NCBI Official Synonym Full Names: phosphoinositide-3-kinase, regulatory subunit 6
• NCBI Official Symbol: PIK3R6
• NCBI Official Synonym Symbols: p84; C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
• NCBI Protein Information: phosphoinositide 3-kinase regulatory subunit 6; p84 PI3K adapter protein; PI3Kgamma adapter protein of 87 kDa; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
• UniProt Protein Name: Phosphoinositide 3-kinase regulatory subunit 6
• Protein Family: Phosphoinositide 3-kinase regulatory
• UniProt Gene Name: PIK3R6
• UniProt Synonym Gene Names: C17orf38; p84 PIKAP; p87PIKAP
• UniProt Entry Name: PI3R6_HUMAN

NCBI Description

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

PIK3R6: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; cytosol

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity

Biological Process: G-protein coupled receptor protein signaling pathway; platelet activation; positive regulation of MAP kinase activity; positive regulation of angiogenesis; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; angiogenesis; blood coagulation; regulation of phosphoinositide 3-kinase activity