Mouse Peroxisomal Biogenesis Factor 6 (PEX6) Monoclonal Antibody | anti-PEX6 antibody

Peroxisomal Biogenesis Factor 6 (PEX6) Monoclonal Antibody

Cat. Num. AAA191360

• Gene Names: PEX6; PAF2; HMLR2; PAF-2; PBD4A; PDB4B; PXAAA1
• Applications: Immunoblot, Western Blot, Immunofluorescence
• Synonyms: Peroxisomal Biogenesis Factor 6 (PEX6); Monoclonal Antibody; Peroxisomal Biogenesis Factor 6 (PEX6) Monoclonal Antibody; anti-PEX6 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: This antibody recognizes human and rat PEX6.
• Form/Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
• Sequence Length: 980

• Applicable Applications for anti-PEX6 antibody: Immunoblot, Immunofluorescence (IF)
• Application Notes: Immunoblot: 1-5ug/ml. A band of ~100kDa is detected.; IF: 10ug/ml; Dilute in PBS or medium that is identical to that used in the assay system.
• Immunogen: Fusion protein corresponding to aa 2-294 (N-terminus) of human PEX6. This sequence is 82% identical in rat and mouse and <50% identical with other PEX proteins.
• Preparation and Storage: This product is stable for at least one (1) year at-20 degree C.

Testing Data

(Detection of PEX6 in rat brain lysate at 5ug/ml.)

Testing Data

(Detection of PEX6 in neuroblastoma cell line SKN-BE at 10ug/ml: DAPI (blue) nuclear stain, Texas Red F actin stain, ATTO 488 (green) PEX6 stain.)

Related Product Information for anti-PEX6 antibody

Peroxisomal Biogenesis Factor 6 (PEX6) is a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. It is predominantly a cytoplasmic protein that plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in the PEX6 gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 194018488
• NCBI GeneID: 5190
• NCBI Accession #: NP_000278.3
• NCBI GenBank Nucleotide #: NM_000287.3
• UniProt Accession #: Q13608; Q5T8W1; Q8WYQ0; Q8WYQ1; Q8WYQ2; Q99476
• Molecular Weight: 77,743 Da
• NCBI Official Full Name: peroxisome biogenesis factor 6 isoform 1
• NCBI Official Synonym Full Names: peroxisomal biogenesis factor 6
• NCBI Official Symbol: PEX6
• NCBI Official Synonym Symbols: PAF2; HMLR2; PAF-2; PBD4A; PDB4B; PXAAA1
• NCBI Protein Information: peroxisome biogenesis factor 6
• UniProt Protein Name: Peroxisome assembly factor 2
• Protein Family: Peroxisomal ATPase
• UniProt Gene Name: PEX6
• UniProt Synonym Gene Names: PXAAA1; PAF-2

NCBI Description

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Description

Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.