Mouse PDZ Domain Containing 1 Monoclonal Antibody | anti-PDZK1 antibody

Mouse Anti Human PDZ Domain Containing 1

Cat. Num. AAA140455

• Applications: ELISA, Western Blot
• Purity: PDZK1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
• Synonyms: PDZ Domain Containing 1; Monoclonal Antibody; Mouse Anti Human PDZ Domain Containing 1; PDZK1 Antibody; Mouse Anti Human; PDZ-Containing Kidney Protein 1; Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3; Na/Pi Cotransporter C-Terminal-Associated Protein 1; Sodium-Hydrogen Exchanger Regulatory Factor 3; CFTR-Associated Protein Of 70 KDa; NHERF-3; CAP70; PDZD1; CLAMP; naPi-Cap1; anti-PDZK1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2B heavy chain and Kappa light chain
• Clone Number: PAT1A2AT
• Purity/Purification: PDZK1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.; Sterile Filtered colorless solution.
• Sequence Length: 519

• Applicable Applications for anti-PDZK1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
• Type: Mouse Anti Human Monoclonal.
• Immunogen: Anti-human PDZK1 mAb, clone PAT1A2A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PDZK1 protein 1-519 amino acids purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-PDZK1 antibody

Introduction: PDZK1 is a PDZ domain-containing scaffolding protein which facilitates localization of cell surface proteins and has a key part in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphism in this gene is linked to metabolic syndrome, and overexpression results in drug resistance of multiple myeloma.

Product Categories/Family for anti-PDZK1 antibody

Monoclonal/Polyclonal Antibodies; Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 55959480
• UniProt Accession #: Q5T2W1; O60450; Q5T5P6; Q9BQ41; B4DPB9; E7EU02
• Molecular Weight: 44,665 Da
• NCBI Official Full Name: PDZ domain containing 1
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: PDZK1
• UniProt Synonym Gene Names: CAP70; NHERF3; PDZD1; NHERF-3; NaPi-Cap1
• UniProt Entry Name: NHRF3_HUMAN

Uniprot Description

PDZK1: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. Belongs to the NHER family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: brush border membrane; microvillus membrane; cytoplasm; apical plasma membrane; plasma membrane; lipid raft

Molecular Function: protein binding; scavenger receptor binding; transporter activity; protein complex binding; PDZ domain binding

Biological Process: cell proliferation; drug transport; transport; carnitine transport