Immunohistochemistry (IHC)
(Fig-1: Immunohistochemical analysis of PAPP-A in human Placenta tissue using PAPP-A antibody (Clone: ABM4C62) at 5 ug/ml.)
Mouse anti-Human PAPP-A Monoclonal Antibody | anti-PAPP-A antibody
Monoclonal Antibody to PAPP-A (Clone: ABM4C62)
Gene Names
PAPPA2; PAPPE; PLAC3; PAPP-E; PAPP-A2
Reactivity
Human
Applications
Immunohistochemistry
Purity
PurifiedProtein G Chromatography
Synonyms
PAPP-A; Monoclonal Antibody; Monoclonal Antibody to PAPP-A (Clone: ABM4C62); Insulin-link growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 proteas; Pregnancy-associated plasma protein A.; anti-PAPP-A antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
ABM4C62
Purity/Purification
Purified
Protein G Chromatography
Protein G Chromatography
Form/Format
25ug in 50ul/100ug in 200ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Sequence Length
1791
Applicable Applications for anti-PAPP-A antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 5-10 ug/ml
Immunogen Information
A partial length recombinant PAPP-A protein (amino acids 332-561) was used as the immunogen for this antibody.
Antigen
PAPP-A
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Immunohistochemistry (IHC)
(Fig-1: Immunohistochemical analysis of PAPP-A in human Placenta tissue using PAPP-A antibody (Clone: ABM4C62) at 5 ug/ml.)
Immunohistochemistry (IHC)
(Fig-1: Immunohistochemical analysis of PAPP-A in human Placenta tissue using PAPP-A antibody (Clone: ABM4C62) at 5 ug/ml.)
Related Product Information for anti-PAPP-A antibody
PAPP-A (pregnancy-associated plasma protein A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. It has prognostic impact in pregnancy and acute coronary syndrome. PAPP-A regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. PAPP-A levels is associated with abnormal glucose metabolism and increased risk of atherosclerosis in AGHD (Adult Growth Hormone Deficiency) patients.
Product Categories/Family for anti-PAPP-A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Pappalysin-2
NCBI Official Synonym Full Names
pappalysin 2
NCBI Official Symbol
PAPPA2
NCBI Official Synonym Symbols
PAPPE; PLAC3; PAPP-E; PAPP-A2
NCBI Protein Information
pappalysin-2
UniProt Protein Name
Pappalysin-2
UniProt Gene Name
PAPPA2
UniProt Synonym Gene Names
PLAC3; PAPP-A2; PAPP-E
NCBI Description
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Uniprot Description
PAPPA2: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. Belongs to the peptidase M43B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: extracellular region
Molecular Function: metalloendopeptidase activity; metallopeptidase activity
Biological Process: cellular protein metabolic process; proteolysis
Research Articles on PAPP-A
Similar Products
Product Notes
The PAPP-A pappa2 (Catalog #AAA668449) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to PAPP-A (Clone: ABM4C62) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PAPP-A can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 5-10 ug/ml. Researchers should empirically determine the suitability of the PAPP-A pappa2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAPP-A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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