Rabbit p23 Monoclonal Antibody | anti-p23 antibody
p23 Conjugated Antibody
Gene Names
PTGES3; P23; TEBP; cPGES
Reactivity
Human, Mouse, Rat
Applications
Most Applications
Synonyms
p23; Monoclonal Antibody; p23 Conjugated Antibody; Co chaperone p23 antibody; cPGES antibody; Cytosolic prostaglandin E synthase antibody; Cytosolic prostaglandin E2 synthase antibody; Hsp90 co chaperone antibody; Hsp90 co-chaperone antibody; P23 antibody; Progesterone receptor complex antibody; Progesterone receptor complex p23 antibody; Prostaglandin E synthase 3 (cytosolic) antibody; Prostaglandin E synthase 3 antibody; PTGES 3 antibody; PTGES3 antibody; Sid 3177 antibody; TEBP antibody; TEBP_HUMAN antibody; Telomerase binding protein p23 antibody; Telomerase-binding protein p23 antibody; Unactive progesterone receptor 23 kD antibody; anti-p23 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Applicable Applications for anti-p23 antibody
Most Applications
Application Notes
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant protein
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Preparation and Storage
Store at 4 degree C for 6 months.
Related Product Information for anti-p23 antibody
P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ERalpha), a steroid complex, to its mature form and to regulate the expression of ERalpha-related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,697 Da
NCBI Official Full Name
prostaglandin E synthase 3
NCBI Official Synonym Full Names
prostaglandin E synthase 3 (cytosolic)
NCBI Official Symbol
PTGES3
NCBI Official Synonym Symbols
P23; TEBP; cPGES
NCBI Protein Information
prostaglandin E synthase 3; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; unactive progesterone receptor, 23 kD
UniProt Protein Name
Prostaglandin E synthase 3
UniProt Gene Name
PTGES3
UniProt Synonym Gene Names
P23; TEBP; cPGES
UniProt Entry Name
TEBP_HUMAN
Uniprot Description
TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family.
Protein type: Transferase; Isomerase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3
Chromosomal Location of Human Ortholog: 12q13.3|12
Cellular Component: nucleoplasm; chromosome, telomeric region; telomerase holoenzyme complex; cytoplasm; nucleus; cytosol
Molecular Function: telomerase activity; protein binding; unfolded protein binding; prostaglandin-E synthase activity
Biological Process: RNA-dependent DNA replication; cyclooxygenase pathway; arachidonic acid metabolic process; prostaglandin biosynthetic process; signal transduction; telomere maintenance
Research Articles on p23
Similar Products
Product Notes
The p23 ptges3 (Catalog #AAA9457316) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p23 Conjugated Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's p23 can be used in a range of immunoassay formats including, but not limited to, Most Applications. Suggested Dilution: AF350 conjugated: most applications: 1:50-1:250 AF405 conjugated: most applications: 1:50-1:250 AF488 conjugated: most applications: 1:50-1:250 AF555 conjugated: most applications: 1:50-1:250 AF594 conjugated: most applications: 1:50-1:250 AF647 conjugated: most applications: 1:50-1:250 AF680 conjugated: most applications: 1:50-1:250 AF750 conjugated: most applications: 1:50-1:250 Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000. Researchers should empirically determine the suitability of the p23 ptges3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p23, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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