Rabbit anti-Human P-Selectin Monoclonal Antibody | anti-SELP antibody
Recombinant Anti-P-Selectin Antibody, Rabbit Monoclonal
Gene Names
SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
P-Selectin; Monoclonal Antibody; Recombinant Anti-P-Selectin Antibody; Rabbit Monoclonal; SELP/P Selectin Antibody; Rabbit MAb; selectin P (granule membrane protein 140kDa; antigen CD62); Anti-CD62 Antibody; Anti-CD62P Antibody; Anti-GMP140 Antibody; Anti-GRMP Antibody; Anti-LECAM3 Antibody; Anti-P-Selectin Antibody; Anti-PADGEM Antibody; Anti-PSEL Antibody; anti-SELP antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
001
Specificity
Human SELP/P Selectin.
No cross-reactivity in ELISA with Human CD62E, Human SELL, Human CAM1, Human CD31, Human VCAM1
No cross-reactivity in ELISA with Human CD62E, Human SELL, Human CAM1, Human CD31, Human VCAM1
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-SELP antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human SELP/P Selectin protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SELP/P Selectin (rh SELP/P Selectin).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-SELP antibody
P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes.
References
Johnson-Tidey RR, et al. (1994) Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. Am J Pathol. 144(5):952-61.Walcheck B, et al. (1996) Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest. 98(5):1081-7.Foreman KE, et al. (1994) C5a-induced expression of P-selectin in endothelial cells. J Clin Invest. 94(3):1147-55.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
90,834 Da
NCBI Official Full Name
selectin P (granule membrane protein 140kDa, antigen CD62)
NCBI Official Synonym Full Names
selectin P
NCBI Official Symbol
SELP
NCBI Official Synonym Symbols
CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
NCBI Protein Information
P-selectin
Protein Family
NCBI Description
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Research Articles on SELP
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Product Notes
The SELP (Catalog #AAA8106638) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-P-Selectin Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's P-Selectin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the SELP for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P-Selectin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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