Mouse anti-Human Omi, HtrA2 Monoclonal Antibody

Omi, HtrA2 (HtrA Serine Peptidase 2, High Temperature Requirement Protein A2, HtrA-like Serine Protease, Omi Stress-regulated Endoprotease, PARK13, Protease Serine 25, PRSS25, Serine Protease 25, Serine Protease HtrA2 Mitochondrial, Serine Protease Omi) (

Cat. Num. AAA632223

• Reactivity: Human
• Applications: ELISA
• Purity: Serum; Serum
• Synonyms: Omi; HtrA2; Monoclonal Antibody; HtrA2 (HtrA Serine Peptidase 2; High Temperature Requirement Protein A2; HtrA-like Serine Protease; Omi Stress-regulated Endoprotease; PARK13; Protease Serine 25; PRSS25; Serine Protease 25; Serine Protease HtrA2 Mitochondrial; Serine Protease Omi) (; Anti -Omi; anti-Omi; HtrA2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, k
• Clone Number: 9A76
• Specificity: This mAb does not crossreact with mouse Omi/HtrA2. Species Crossreactivity: Human
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

• Applicable Applications for anti-Omi, HtrA2 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: This monoclonal antibody was developed by immunizing mice with a synthetic peptide containing amino acids 335-350 of human Omi/HtrA2.
• Positive Control: Jurkat or HL-60 cell lysate can also be used as a positive control.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Omi, HtrA2 antibody

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DAIBLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.

Product Categories/Family for anti-Omi, HtrA2 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)