Mouse anti-Mouse NKR-P1-A,B,C Monoclonal Antibody | anti-NKR-P1-A,B,C antibody
NKR-P1-A,B,C
Gene Names
Klrb1a; Ly55a; NKRP12; Nkrp1a; ly-55A; NKR-P1A; Nkrp1-a; NKR-P1.7
Reactivity
Mouse
Applications
Immunoprecipitation, Western Blot, Flow Cytometry, Functional Assay
Purity
Protein A/G Chromatography
Synonyms
NKR-P1-A; B; C; Monoclonal Antibody; anti-NKR-P1-A; C antibody
Host
Mouse
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
1C10
Purity/Purification
Protein A/G Chromatography
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Sequence Length
200
Applicable Applications for anti-NKR-P1-A,B,C antibody
Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)
Immunogen
Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c X C57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cell line.
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Related Product Information for anti-NKR-P1-A,B,C antibody
Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.
Product Categories/Family for anti-NKR-P1-A,B,C antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,782 Da
NCBI Official Full Name
killer cell lectin-like receptor subfamily B member 1A isoform 2
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily B member 1A
NCBI Official Symbol
Klrb1a
NCBI Official Synonym Symbols
Ly55a; NKRP12; Nkrp1a; ly-55A; NKR-P1A; Nkrp1-a; NKR-P1.7
NCBI Protein Information
killer cell lectin-like receptor subfamily B member 1A; NKR-P1 2; lymphocyte antigen 55A; natural killer cell receptor-P1; CD161 antigen-like family member A; lymphocyte antigen 55 complex, locus A; natural killer cell surface protein P1-2; natural killer cell receptor protein NKR-P1A
UniProt Protein Name
Killer cell lectin-like receptor subfamily B member 1A
UniProt Gene Name
Klrb1a
UniProt Synonym Gene Names
Ly55; Ly55a; Nkrp1a; NKR-P1A; Ly-55A; NKR-P1 2
UniProt Entry Name
KLRBA_MOUSE
Uniprot Description
Function: Plays a stimulatory role on natural killer (NK) cell cytotoxicity. Ref.6
Subunit structure: Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK
By similarity. Ref.8
Subcellular location: Membrane; Single-pass type II membrane protein.
Tissue specificity: Expressed in natural killer cells.
Sequence similarities: Contains 1 C-type lectin domain.
Research Articles on NKR-P1-A,B,C
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Product Notes
The NKR-P1-A,B,C klrb1a (Catalog #AAA395328) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NKR-P1-A,B,C reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NKR-P1-A,B,C can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the NKR-P1-A,B,C klrb1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NKR-P1-A,B,C, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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