Testing Data
Mouse anti-Human NGFR Monoclonal Antibody | anti-NGFR antibody
NGFR Antibody (Clone # 8G3G10)
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
Background: NGFR, a 75 kd glycoprotein (also known as P-75NTR), is the first of neurotrophin receptors to be isolated and is a member of the tumor necrosis factor (TNF) receptor family. It is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, and neurotized nevi (type C melanocytes). NGFR has been shown to be a reliable marker for desmoplastic and neurotropic melanoma by several groups. It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature nonneural cells such as perivascular cells, follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells and myoepithelial cells. Studies in prostate and urothelial cancer suggest that NGFR may act as a tumour suppressor, negatively regulating cell growth and proliferation. Anti-NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts and thus aides in the identification of malignancy in the breast.
NCBI and Uniprot Product Information
NCBI Description
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
Uniprot Description
NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21-q22
Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; extracellular region; plasma membrane; cytosol; endosome
Molecular Function: signal transducer activity; protein binding; transmembrane receptor activity; ubiquitin protein ligase binding; death receptor activity; nerve growth factor binding; receptor activity; Rab GTPase binding
Biological Process: detection of temperature stimulus; axon guidance; membrane protein intracellular domain proteolysis; central nervous system development; hair follicle morphogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of odontogenesis of dentine-containing teeth; regulation of caspase activity; regulation of axonogenesis; glucose homeostasis; negative regulation of hair follicle development; negative regulation of cell cycle; intracellular protein transport; positive regulation of fibroblast proliferation; negative regulation of axonogenesis; positive regulation of axonogenesis; nerve development; circadian regulation of gene expression; negative regulation of apoptosis
Research Articles on NGFR
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Product Notes
The NGFR ngfr (Catalog #AAA840067) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NGFR Antibody (Clone # 8G3G10) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NGFR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC). WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:100. Researchers should empirically determine the suitability of the NGFR ngfr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NGFR, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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