Mouse anti-Human Myoglobin Monoclonal Antibody | anti-MB antibody

Myoglobin Mouse mAb

Cat. Num. AAA8538323

• Gene Names: MB; PVALB; myoglobgin
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry, Functional Assay, ELISA
• Purity: Affinity Purified
• Synonyms: Myoglobin; Monoclonal Antibody; Myoglobin Mouse mAb; PVALB; MGC13548; anti-MB antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 5A2G8
• Purity/Purification: Affinity Purified
• Form/Format: In PBS containing 0.03% Sodium Azide.
• Sequence Length: 154

• Applicable Applications for anti-MB antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of Myoglobin expressed in E. Coli.
• Preparation and Storage: Store at 4 degree C short term. Store at -20 degree C long term. Avoid freeze/thaw cycle.

Related Product Information for anti-MB antibody

Myoglobin (MB), with 154-amino acid protein (about 17kDa), is a member of the globin superfamily and expression of myoglobin is highest in skeletal and cardiac muscle. Functionally, myoglobin is well accepted as an O2-storage protein in muscle, capable of releasing O2 during periods of hypoxia or anoxia. Myoglobin is also thought to buffer intracellular O2 concentration when muscle activity increases and to facilitate intracellular O2 diffusion by providing a parallel path that augments simple diffusion of dissolved O2. Furthermore, myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI identification.

NCBI and Uniprot Product Information

• NCBI GI #: 4885477
• NCBI GeneID: 4151
• NCBI Accession #: NP_005359.1
• NCBI GenBank Nucleotide #: NP_005359.1
• UniProt Accession #: P02144
• NCBI Official Full Name: myoglobin
• NCBI Official Synonym Full Names: myoglobin
• NCBI Official Symbol: MB
• NCBI Official Synonym Symbols: PVALB; myoglobgin
• NCBI Protein Information: myoglobin
• UniProt Protein Name: Myoglobin
• Protein Family: Myoglobin
• UniProt Gene Name: MB
• UniProt Entry Name: MYG_HUMAN

NCBI Description

This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

MB: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 22q13.1

Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: slow-twitch skeletal muscle fiber contraction; response to hydrogen peroxide; oxygen transport; heart development; response to hormone stimulus; response to hypoxia; brown fat cell differentiation; enucleate erythrocyte differentiation