Western Blot (WB)
(Western Blot detection against Immunogen (36.01kD).)
Mouse anti-Human MYO3A Monoclonal Antibody | anti-MYO3A antibody
MYO3A (Myosin-IIIa)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot detection against Immunogen (36.01kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (36.01kD).)
Western Blot (WB)
(MYO3A monoclonal antibody, Western Blot analysis of MYO3A expression in Hela NE.)
Western Blot (WB)
(MYO3A monoclonal antibody, Western Blot analysis of MYO3A expression in Hela NE.)
Testing Data
(Detection limit for recombinant GST tagged MYO3A is ~1ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged MYO3A is ~1ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
Uniprot Description
MYO3A: a multifunctional protein with an N-terminal kinase domain of the STE20 family and a myosin-head motor domain. Expression of this gene is highly restricted, with the strongest expression in photoreceptors and cochlea. Probably plays a role in vision and hearing. 3 different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss.
Protein type: Protein kinase, STE; Kinase, protein; Actin-binding; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Motor; STE group; STE20 family; NinaC subfamily
Chromosomal Location of Human Ortholog: 10p11.1
Cellular Component: filamentous actin; filopodium tip; photoreceptor inner segment; cytoplasm; stereocilium bundle tip; myosin complex; filopodium
Molecular Function: actin filament binding; microfilament motor activity; calmodulin binding; protein serine/threonine kinase activity; plus-end directed microfilament motor activity; actin-dependent ATPase activity; ADP binding; ATP binding; protein kinase activity
Biological Process: positive regulation of filopodium formation; peptidyl-serine phosphorylation; sensory perception of sound; visual perception; protein amino acid autophosphorylation; response to stimulus; peptidyl-threonine phosphorylation; inner ear development
Disease: Deafness, Autosomal Recessive 30
Research Articles on MYO3A
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Product Notes
The MYO3A myo3a (Catalog #AAA6002880) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MYO3A (Myosin-IIIa) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MYO3A can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the MYO3A myo3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HEEINNIKKK DNKDSKATSE REACGLAIFS KQISKLSEEY FILQKKLNEM ILSQQLKSLY LGVSHHKPIN RRVSSQQCLS GVCKGEEPKI L. It is sometimes possible for the material contained within the vial of "MYO3A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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