Western Blot (WB)
(Western Blot analysis of MYO3A expression in transfected 293T cell line by MYO3A polyclonal antibody. Lane 1: MYO3A transfected lysate (27.6kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human MYO3A Polyclonal Antibody | anti-MYO3A antibody
MYO3A (Myosin-IIIa)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of MYO3A expression in transfected 293T cell line by MYO3A polyclonal antibody. Lane 1: MYO3A transfected lysate (27.6kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of MYO3A expression in transfected 293T cell line by MYO3A polyclonal antibody. Lane 1: MYO3A transfected lysate (27.6kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Ref.2
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subcellular location: Cytoplasm › cytoskeleton.
Tissue specificity: Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas.
Involvement in disease: Deafness, autosomal recessive, 30 (DFNB30) [MIM:607101]: A form of non-syndromic deafness characterized by bilateral progressive hearing loss, which first affects the high frequencies. Hearing loss begins in the second decade, and by age 50 is severe in high and middle frequencies and moderate at low frequencies.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2
Sequence similarities: In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.Contains 3 IQ domains.Contains 1 myosin head-like domain.Contains 1 protein kinase domain.
Research Articles on MYO3A
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Product Notes
The MYO3A myo3a (Catalog #AAA645984) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MYO3A (Myosin-IIIa) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MYO3A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the MYO3A myo3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MFPLIGKTII FDNFPDPSDT WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPIHDIDE EIEAGYNILK ALSDHPNVVR FYGIYFKKDK VNGDKLWLVL ELCSGGSVTD LVKGFLKRGE RMSEPLIAYI LHEALMGLQH LHNNKTIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRH RRNTSVGTPF WMAPEVIACE QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF KIPRSDD. It is sometimes possible for the material contained within the vial of "MYO3A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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