Western Blot (WB)
(Western Blot analysis in T47D cell line lysates using (35ug/lane). This demonstrates the MX1 antibody detected the MX1 protein (arrow).)
Mouse anti-Human MX1 Monoclonal Antibody | anti-MX1 antibody
MX1 (MX1, Interferon-induced GTP-binding protein Mx1, Interferon-induced protein p78, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, Interferon-induced GTP-binding protein Mx1, N-termi
Gene Names
MX1; MX; MxA; IFI78; IFI-78K
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein G Affinity Chromatography
Synonyms
MX1; Monoclonal Antibody; MX1 (MX1; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1; N-termi; N-terminally processed; anti-MX1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
474CT4.1.5
Specificity
Recognizes human MX1.
Purity/Purification
Purified by Protein G Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Applicable Applications for anti-MX1 antibody
FLISA, Western Blot (WB)
Application Notes
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.
WB: 1:100-500
Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 617-646 of human MX1, UniProt Accession #P20591. Species Sequence Homology: porcine
Conjugate
FITC
Special Handling
Light sensitive
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Western Blot (WB)
(Western Blot analysis in T47D cell line lysates using (35ug/lane). This demonstrates the MX1 antibody detected the MX1 protein (arrow).)
Western Blot (WB)
(Western Blot analysis in T47D cell line lysates using (35ug/lane). This demonstrates the MX1 antibody detected the MX1 protein (arrow).)
Related Product Information for anti-MX1 antibody
In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene.
Product Categories/Family for anti-MX1 antibody
References
1. Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010). 2. van der Voort, L.F., et al. Neurology 75(14):1228-1233(2010). 3. Ching, J.C., et al. J. Infect. Dis. 201(12):1899-1908(2010). 4. Zhijian, Y., et al. Virol. J. 7, 278 (2010). 5. Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
55,661 Da
NCBI Official Full Name
interferon-induced GTP-binding protein Mx1 isoform a
NCBI Official Synonym Full Names
MX dynamin like GTPase 1
NCBI Official Symbol
MX1
NCBI Official Synonym Symbols
MX; MxA; IFI78; IFI-78K
NCBI Protein Information
interferon-induced GTP-binding protein Mx1
UniProt Protein Name
Interferon-induced GTP-binding protein Mx1
Protein Family
UniProt Gene Name
MX1
UniProt Synonym Gene Names
IFI-78K
UniProt Entry Name
MX1_HUMAN
Uniprot Description
MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Apoptosis
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: GTPase activity; protein binding; GTP binding
Biological Process: negative regulation of viral genome replication; apoptosis; metabolic process; cytokine and chemokine mediated signaling pathway; response to virus; innate immune response; defense response; signal transduction; defense response to virus
Similar Products
Product Notes
The MX1 mx1 (Catalog #AAA6121387) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MX1 (MX1, Interferon-induced GTP-binding protein Mx1, Interferon-induced protein p78, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, Interferon-induced GTP-binding protein Mx1, N-termi reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MX1 can be used in a range of immunoassay formats including, but not limited to, FLISA, Western Blot (WB). FLISA: 1:1,000 WB: 1:100-500 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the MX1 mx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MX1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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