Mouse anti-Human, Mouse Musashi-1 Monoclonal Antibody | anti-MSI1 antibody

Musashi-1 Antibody

Cat. Num. AAA9215597

• Reactivity: Human, Mouse
• Applications: Western Blot
• Synonyms: Musashi-1; Monoclonal Antibody; Musashi-1 Antibody; Purified Mouse Monoclonal Antibody (Mab); MSI1; Msi 1; Msi1; MSI1H_HUMAN; Musashi homolog 1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1.; anti-MSI1 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Form/Format: Purified mouse monoclonal in PBS(pH 7.4) containing with 0.2% sodium azide, 50% glycerol, 0.1%BSA
• Sequence Length: 362

• Applicable Applications for anti-MSI1 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:1000
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of Musashi-1 in U87MG,C6,IMR32,mouse brain and PC12 cell lysates and using Musashi-1 mouse mAb (1:1000 diluted).Predicted band size: 39KDa.Observed band size:39KDa.)

Related Product Information for anti-MSI1 antibody

RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Product Categories/Family for anti-MSI1 antibody

Neuroscience; Stem Cells

References

Good P.,et al.Genomics 52:382-384(1998). Scherer S.E.,et al.Nature 440:346-351(2006). Shu H.-J.,et al.Biochem. Biophys. Res. Commun. 293:150-154(2002). Okano H.,et al.J. Cell Sci. 115:1355-1359(2002). Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4505255
• NCBI GeneID: 4440
• NCBI Accession #: NP_002433.1
• NCBI GenBank Nucleotide #: NM_002442.3
• UniProt Accession #: O43347; Q96PU0; Q96PU1; Q96PU2; Q96PU3
• Molecular Weight: 39125
• NCBI Official Full Name: RNA-binding protein Musashi homolog 1
• NCBI Official Synonym Full Names: musashi RNA binding protein 1
• NCBI Official Symbol: MSI1
• NCBI Protein Information: RNA-binding protein Musashi homolog 1
• UniProt Protein Name: RNA-binding protein Musashi homolog 1
• Protein Family: RNA-binding protein
• UniProt Gene Name: MSI1
• UniProt Synonym Gene Names: Musashi-1
• UniProt Entry Name: MSI1H_HUMAN

NCBI Description

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

Uniprot Description

Musashi-1: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. Belongs to the Musashi family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: polysome; cytoplasm; nucleus

Molecular Function: RNA binding; nucleotide binding; poly(U) binding

Biological Process: nervous system development