Mouse anti-Human, Rat MTMR2 Monoclonal Antibody | anti-MTMR2 antibody

MTMR2 (Myotubularin-related Protein 2, CMT4B, CMT4B1, KIAA1073) APC

Cat. Num. AAA6137722

• Gene Names: MTMR2; CMT4B; CMT4B1
• Reactivity: Human, Rat
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MTMR2; Monoclonal Antibody; MTMR2 (Myotubularin-related Protein 2; CMT4B; CMT4B1; KIAA1073) APC; anti-MTMR2 antibody

• Host: Mouse
• Reactivity: Human, Rat
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 4G6
• Specificity: Recognizes human MTMR2. Species Crossreactivity: rat.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
• Sequence Length: 643

• Applicable Applications for anti-MTMR2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa5-100, from human MTMR2 (NP_057240) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: SSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGA
• Conjugate: APC
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (36.67kD).)

Western Blot (WB)

(MTMR2 monoclonal antibody Western Blot analysis of MTMR2 expression in HeLa.)

Western Blot (WB)

(MTMR2 monoclonal antibody Western Blot analysis of MTMR2 expression in PC-12.)

Western Blot (WB)

(Western Blot analysis of MTMR2 expression in transfected 293T cell line by MTMR2 monoclonal antibody Lane 1: MTMR2 transfected lysate (66kD). Lane 2: Non-transfected lysate.)

Testing Data

(Detection limit for recombinant GST tagged MTMR2 is ~0.3ng/ml as a capture antibody.)

Related Product Information for anti-MTMR2 antibody

This gene is a member of the myotubularin family and encodes a putative tyrosine phosphatase. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene, but the protein products of some of these variants are likely not viable, as they are nonsense-mediated mRNA decay (NMD) candidates. [provided by RefSeq]

Product Categories/Family for anti-MTMR2 antibody

Antibodies; Protein Phosphatases

References

1. Dlg1, Sec8, and Mtmr2 Regulate Membrane Homeostasis in Schwann Cell Myelination. Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A.J Neurosci. 2009 Jul 8;29(27):8858-70.

NCBI and Uniprot Product Information

• NCBI GI #: 44680154
• NCBI GeneID: 8898
• NCBI Accession #: NP_057240
• NCBI GenBank Nucleotide #: NM_016156
• UniProt Accession #: Q13614
• NCBI Official Full Name: myotubularin-related protein 2 isoform 1
• NCBI Official Synonym Full Names: myotubularin related protein 2
• NCBI Official Symbol: MTMR2
• NCBI Official Synonym Symbols: CMT4B; CMT4B1
• NCBI Protein Information: myotubularin-related protein 2
• UniProt Protein Name: Myotubularin-related protein 2
• Protein Family: Myotubularin-related protein
• UniProt Gene Name: MTMR2
• UniProt Entry Name: MTMR2_HUMAN

NCBI Description

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]