Mouse Mre11 Monoclonal Antibody | anti-Mre11a antibody
Mre11 Monoclonal Antibody
This antibody recognizes human Mre11, an 80 kD protein that acts as a Mn+2- dependent double stranded DNA 3' to 5' exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (Nibrin), and possibly other proteins involved in the nucleolytic end-processing of double strand breaks and telomere maintenance.
Positive control: T24 cells, recombinant fusion protein.
NCBI and Uniprot Product Information
NCBI Description
may play a role in regulation of cardiomyocyte proliferation [RGD]
Uniprot Description
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: Deoxyribonuclease; DNA repair, damage; Cell cycle regulation; DNA-binding
Cellular Component: nucleoplasm; chromosome, telomeric region; Mre11 complex; condensed nuclear chromosome; perinuclear region of cytoplasm; nuclear chromatin; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; endonuclease activity; manganese ion binding; exonuclease activity; 3'-5' exonuclease activity
Biological Process: negative regulation of virion penetration into host cell; heart development; positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; positive regulation of protein amino acid autophosphorylation; chromosome organization and biogenesis; DNA duplex unwinding; cell proliferation; meiotic cell cycle; base-excision repair; nucleotide-excision repair; intra-S DNA damage checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; double-strand break repair; synapsis; telomere maintenance; response to DNA damage stimulus
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Product Notes
The Mre11a mre11a (Catalog #AAA190331) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Mre11 can be used in a range of immunoassay formats including, but not limited to, Immunoblot, Immunoprecipitation. Immunoblotting, immunoprecipitation: use at 1-5 ug/ml. Positive control: T24 cells, recombinant fusion protein. Researchers should empirically determine the suitability of the Mre11a mre11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mre11, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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