Rabbit MRE11 Polyclonal Antibody | anti-MRE11 antibody

MRE11 Rabbit Polyclonal

Cat. Num. AAA7601539

• Gene Names: Mre11a; Mre11
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MRE11; Polyclonal Antibody; MRE11 Rabbit Polyclonal; anti-MRE11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 706

• Applicable Applications for anti-MRE11 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lymphoma using MBS7601539 (MRE11A antibody) at dilution of 1:50)

Western Blot (WB)

(A431 cells were subjected to SDS PAGE followed by western blot with MBS7601539 (MRE11A antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 9651646
• NCBI GeneID: 64046
• Molecular Weight: 80,122 Da
• NCBI Official Full Name: MRE11
• NCBI Official Synonym Full Names: MRE11 homolog A, double strand break repair nuclease
• NCBI Official Symbol: Mre11a
• NCBI Official Synonym Symbols: Mre11
• NCBI Protein Information: double-strand break repair protein MRE11A
• UniProt Protein Name: Double-strand break repair protein MRE11A
• Protein Family: Double-strand break repair protein
• UniProt Gene Name: Mre11a
• UniProt Synonym Gene Names: Mre11; MRE11 homolog 1; MRE11 homolog A
• UniProt Entry Name: MRE11_RAT

NCBI Description

may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]

Uniprot Description

MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: Cell cycle regulation; Deoxyribonuclease; DNA-binding; DNA repair, damage

Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body

Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; endodeoxyribonuclease activity; endonuclease activity; manganese ion binding; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity

Biological Process: cell proliferation; chromosome organization and biogenesis; DNA duplex unwinding; double-strand break repair; double-strand break repair via nonhomologous end joining; heart development; intra-S DNA damage checkpoint; meiotic cell cycle; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomeric 3' overhang formation