Western Blot (WB)
(Western Blot analysis of PC-3 cells using Melanophilin Monoclonal Antibody at dilution of 1:1000)
Mouse anti-Human MLPH Monoclonal Antibody | anti-MLPH antibody
MLPH Monoclonal Antibody
Gene Names
MLPH; SLAC2-A
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Purity
Protein G purification
Synonyms
MLPH; Monoclonal Antibody; MLPH Monoclonal Antibody; 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; Exophilin 3; Exophilin-3; l(1)-3Rk; l1Rk3; Leaden; Leaden protein; ln; Melanophilin; MELPH; MGC2771; MGC59733; Mlph; Slac 2a; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin like protein 2a; Synaptotagmin like protein lacking C2 domains A; Synaptotagmin-like protein 2a; anti-MLPH antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
72
Purity/Purification
Protein G purification
Concentration
1mg/mL (varies by lot)
Sequence Length
572
Applicable Applications for anti-MLPH antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:10-1:100
IHC: 1:20-1:200
IF: 1:10-1:100
Immunogen
Fusion protein of Melanophilin
Buffer
PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Western Blot (WB)
(Western Blot analysis of PC-3 cells using Melanophilin Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of PC-3 cells using Melanophilin Monoclonal Antibody at dilution of 1:1000)
Related Product Information for anti-MLPH antibody
Melanophilin (MLPH) is a member of the exophilin subfamily of Rab effector proteins. MLPH is a modular protein, forming a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. It regulates retention of melanosomes at the peripheral actin cytoskeleton of melanocytes, a process essential for normal mammalian pigmentation. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3), which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft.
Product Categories/Family for anti-MLPH antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated: 66kDa
Observed: 66kDa; 63kDa
Observed: 66kDa; 63kDa
NCBI Official Full Name
melanophilin isoform 2
NCBI Official Synonym Full Names
melanophilin
NCBI Official Symbol
MLPH
NCBI Official Synonym Symbols
SLAC2-A
NCBI Protein Information
melanophilin
UniProt Protein Name
Melanophilin
Protein Family
UniProt Gene Name
MLPH
UniProt Synonym Gene Names
SLAC2A; SlaC2-a
NCBI Description
This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Description
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
Research Articles on MLPH
Similar Products
Product Notes
The MLPH mlph (Catalog #AAA2541981) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MLPH Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MLPH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). WB: 1:500-1:5000 IHC: 1:20-1:200 IF: 1:10-1:100. Researchers should empirically determine the suitability of the MLPH mlph for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLPH, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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