Mouse MHC Class II Monoclonal Antibody | anti-MHC Class II antibody
Mouse Anti MHC Class II (I-A)
Purity
Ion exchange column.
Synonyms
MHC Class II; Monoclonal Antibody; Mouse Anti MHC Class II (I-A); I-A Antibody; (I-A) Mouse Antibody; anti-MHC Class II antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
NYRmI-A
Specificity
Recognizes most MHC class II haplotypes (b,f,p,q,r,s,u,v), but weak against I-Ak.
Purity/Purification
Ion exchange column.
Concentration
1mg/ml in PBS (after reconstitution). (varies by lot)
Sequence Length
229
Reconstitution
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen
Purified mouse LN B cells (C3H anti-C57Bl6).
Antibody Properties
Cytotoxic and staining antibody. For staining, use 10ml/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator.
Available Conjugates
This antibody is also available conjugated to biotin and FITC.
Preparation and Storage
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Related Product Information for anti-MHC Class II antibody
Introduction: MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
Product Categories/Family for anti-MHC Class II antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
26,489 Da
NCBI Official Full Name
MHC class II HLA-DQ-beta-1
UniProt Protein Name
MHC class II HLA-DQ-beta-1
Protein Family
UniProt Gene Name
HLA-DQB1
UniProt Entry Name
O19707_HUMAN
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Product Notes
The MHC Class II hla-dqb1 (Catalog #AAA140116) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MHC Class II, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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