Mouse anti-Human LYST Monoclonal Antibody | anti-LYST antibody

LYST (Lysosomal-trafficking Regulator, Beige Homolog, CHS, CHS1) (PE)

Cat. Num. AAA6158683

• Gene Names: LYST; CHS; CHS1
• Reactivity: Human
• Applications: FLISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LYST; Monoclonal Antibody; LYST (Lysosomal-trafficking Regulator; Beige Homolog; CHS; CHS1) (PE); anti-LYST antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: 3H1
• Specificity: Recognizes human LYST.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-LYST antibody: FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa1-100 from human LYST with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPL
• Conjugate: PE
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged LYST is 0.03ng/ml as a capture antibody)

Related Product Information for anti-LYST antibody

May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.

Product Categories/Family for anti-LYST antibody

Antibodies; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 54292123
• NCBI GeneID: 1130
• NCBI Accession #: NP_000072.2
• NCBI GenBank Nucleotide #: NM_000081
• UniProt Accession #: Q99698; O43274; Q5T2U9; Q96TD7; Q96TD8; Q99709; Q9H133
• Molecular Weight: 429,139 Da
• NCBI Official Full Name: lysosomal-trafficking regulator
• NCBI Official Synonym Full Names: lysosomal trafficking regulator
• NCBI Official Symbol: LYST
• NCBI Official Synonym Symbols: CHS; CHS1
• NCBI Protein Information: lysosomal-trafficking regulator; beige homolog; Chediak-Higashi syndrome 1
• UniProt Protein Name: Lysosomal-trafficking regulator
• Protein Family: Lysosomal-trafficking regulator
• UniProt Gene Name: LYST
• UniProt Synonym Gene Names: CHS; CHS1
• UniProt Entry Name: LYST_HUMAN

NCBI Description

This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]

Uniprot Description

LYST: May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. Defects in LYST are the cause of Chediak-Higashi syndrome (CHS). CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42.1-q42.2

Cellular Component: microtubule cytoskeleton; extrinsic to membrane; endomembrane system; cytosol

Molecular Function: protein binding; phospholipid binding

Biological Process: response to drug; secretion of lysosomal enzymes; natural killer cell mediated cytotoxicity; T cell mediated immunity; leukocyte chemotaxis; neutrophil mediated immunity; mast cell secretory granule organization and biogenesis; defense response to protozoan; endosome to lysosome transport via multivesicular body sorting pathway; positive regulation of natural killer cell activation; microtubule-based process; pigmentation; melanosome organization and biogenesis; lysosome organization and biogenesis; phospholipid metabolic process; defense response to bacterium; blood coagulation; defense response to virus; phospholipid homeostasis

Disease: Chediak-higashi Syndrome