Testing Data
(THP-1 cells were stained with PE-conjugated anti-human LAMP1/CD107a | or isotype control .)
Mouse anti-Human Lysosome-associated Membrane Protein-1 Monoclonal Antibody | anti-LAMP1 antibody
Lysosome-associated Membrane Protein-1 (LAMP1, LAMP-1, CD107a Antigen, LAMPA, LGP120, Lysosome-associated Membrane Glycoprotein 1 Precursor) (PE)
Gene Names
LAMP1; LAMPA; CD107a; LGP120
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
Lysosome-associated Membrane Protein-1; Monoclonal Antibody; Lysosome-associated Membrane Protein-1 (LAMP1; LAMP-1; CD107a Antigen; LAMPA; LGP120; Lysosome-associated Membrane Glycoprotein 1 Precursor) (PE); Anti -Lysosome-associated Membrane Protein-1 (LAMP1; anti-LAMP1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9H151
Specificity
Recognizes human LAMP-1.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder in 25ug antibody, 1ml saline, 0.5% BSA, 0.1% sodium azide. Reconstitute with 40-50% glycerol, PBS.
Applicable Applications for anti-LAMP1 antibody
Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in Flow Cytometry.
Immunogen
NS0-derived, recombinant human LAMP-1 aa 28-380.
Preparation and Storage
Maybe stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 6 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Testing Data
(THP-1 cells were stained with PE-conjugated anti-human LAMP1/CD107a | or isotype control .)
Testing Data
(THP-1 cells were stained with PE-conjugated anti-human LAMP1/CD107a | or isotype control .)
Related Product Information for anti-LAMP1 antibody
LAMP1 (Lysosome-associated membrane protein-1; also known as CD107a) is a 100-130kD member of the LAMP family of glycoproteins. It is expressed in lysosomal and plasma membranes of macrophages, NK and T cells, and is essential for the formation of phagolysosomes, along with LAMP2. On the cell surface, LAMP1 also presents carbohydrates to selectins. Mature human LAMP1 is a 389 aa type I transmembrane glycoprotein. It contains a 354aa luminal/extracellular domain (ECD) (aa28-381) and a 12aa cytoplasmic tail (aa405- 416). The ECD has two large looping regions (aa28-193 and 227-381) plus multiple N- and O-linked glycosylation sites.
Product Categories/Family for anti-LAMP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,882 Da
NCBI Official Full Name
lysosome-associated membrane glycoprotein 1
NCBI Official Synonym Full Names
lysosomal-associated membrane protein 1
NCBI Official Symbol
LAMP1
NCBI Official Synonym Symbols
LAMPA; CD107a; LGP120
NCBI Protein Information
lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1
UniProt Protein Name
Lysosome-associated membrane glycoprotein 1
Protein Family
UniProt Gene Name
LAMP1
UniProt Synonym Gene Names
LAMP-1
UniProt Entry Name
LAMP1_HUMAN
NCBI Description
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
Uniprot Description
LAMP1: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: integral to plasma membrane; lysosome; dendrite; multivesicular body; membrane; cell soma; cytoplasm; late endosome; plasma membrane; melanosome; endosome membrane; sarcolemma; external side of plasma membrane
Molecular Function: protein domain specific binding; protein binding; enzyme binding
Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; protein stabilization; viral reproduction; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity
Research Articles on LAMP1
Similar Products
Product Notes
The LAMP1 lamp1 (Catalog #AAA608184) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Lysosome-associated Membrane Protein-1 (LAMP1, LAMP-1, CD107a Antigen, LAMPA, LGP120, Lysosome-associated Membrane Glycoprotein 1 Precursor) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lysosome-associated Membrane Protein-1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry. Researchers should empirically determine the suitability of the LAMP1 lamp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lysosome-associated Membrane Protein-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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