Western Blot (WB)
(LTB Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LTB antibody detected the LTB protein (arrow).)
Mouse LTB Monoclonal Antibody | anti-LTB antibody
LTB Antibody (C-term)
Western Blot (WB)
(LTB Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LTB antibody detected the LTB protein (arrow).)
Western Blot (WB)
(LTB Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LTB antibody detected the LTB protein (arrow).)
family. It anchors lymphotoxin-alpha to the cell surface through
heterotrimer formation. The predominant form on the lymphocyte
surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule
alpha/2 molecules beta) and this complex is the primary ligand for
the lymphotoxin-beta receptor. The minor complex is
lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory
response system and involved in normal development of lymphoid
tissue. Lymphotoxin-beta isoform b is unable to complex with
lymphotoxin-alpha suggesting a function for lymphotoxin-beta which
is independent of lympyhotoxin-alpha. Alternative splicing results
in multiple transcript variants encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Young, J., et al. Cytokine 51(1):78-86(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
LTB: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: extracellular space; integral to membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding
Biological Process: skin development; positive regulation of interleukin-12 biosynthetic process; cell-cell signaling; immune response; gene expression; signal transduction; lymph node development
Research Articles on LTB
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Product Notes
The LTB ltb (Catalog #AAA9200359) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 199-227. The LTB Antibody (C-term) reacts with Human (Predicted Reactivity: Pig) and may cross-react with other species as described in the data sheet. AAA Biotech's LTB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:100~500. Researchers should empirically determine the suitability of the LTB ltb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LTB, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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