Rabbit LTB Polyclonal Antibody | anti-LTB antibody

LTB Polyclonal Antibody

Cat. Num. AAA2529018

• Gene Names: LTB; p33; TNFC; TNFSF3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: LTB; Polyclonal Antibody; LTB Polyclonal Antibody; p33; TNFC; TNFSF3; anti-LTB antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.8mg/mL (varies by lot)
• Sequence Length: 244

• Applicable Applications for anti-LTB antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:30-1:150
• Immunogen: Synthetic peptide of human LTB
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LTB Polyclonal Antibody at dilution 1:45)

Related Product Information for anti-LTB antibody

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e. g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 114306789
• NCBI GeneID: 4050
• Molecular Weight: 7,780 Da
• NCBI Official Full Name: LTB protein
• NCBI Official Synonym Full Names: lymphotoxin beta (TNF superfamily, member 3)
• NCBI Official Symbol: LTB
• NCBI Official Synonym Symbols: p33; TNFC; TNFSF3
• NCBI Protein Information: lymphotoxin-beta; LT-beta; TNF-C; tumor necrosis factor C; tumor necrosis factor ligand superfamily member 3
• UniProt Protein Name: Lymphotoxin-beta
• Protein Family: Lymphotoxin
• UniProt Gene Name: LTB
• UniProt Synonym Gene Names: TNFC; TNFSF3; LT-beta; TNF-C
• UniProt Entry Name: TNFC_HUMAN

NCBI Description

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

LTB: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: skin development; positive regulation of interleukin-12 biosynthetic process; cell-cell signaling; immune response; gene expression; signal transduction; lymph node development