Western Blot (WB)
(Western Blot analysis of LPIN1 expression in transfected 293T cell line by LPIN1 monoclonal antibody.|Lane 1: LPIN1 transfected lysate (Predicted MW: 98.7kD).|Lane 2: Non-transfected lysate.)
Mouse anti-Human LPIN1 Monoclonal Antibody | anti-Lpin1 antibody
LPIN1 (KIAA0188, Phosphatidate Phosphatase LPIN1, Lipin-1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of LPIN1 expression in transfected 293T cell line by LPIN1 monoclonal antibody.|Lane 1: LPIN1 transfected lysate (Predicted MW: 98.7kD).|Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of LPIN1 expression in transfected 293T cell line by LPIN1 monoclonal antibody.|Lane 1: LPIN1 transfected lysate (Predicted MW: 98.7kD).|Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
Uniprot Description
LPIN1: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family.
Protein type: EC 3.1.3.4; Phosphatase, lipid
Cellular Component: mitochondrial outer membrane; transcription factor complex; nuclear membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; nucleus
Molecular Function: protein binding; peroxisome proliferator activated receptor binding; hydrolase activity; phosphatidate phosphatase activity; histone deacetylase binding; transcription coactivator activity
Biological Process: fat cell differentiation; mitochondrial fission; transcription, DNA-dependent; regulation of fat cell differentiation; triacylglycerol biosynthetic process; fatty acid catabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; dephosphorylation; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; actin cytoskeleton reorganization; ruffle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; triacylglycerol mobilization
Research Articles on Lpin1
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Product Notes
The Lpin1 lpin1 (Catalog #AAA642396) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The LPIN1 (KIAA0188, Phosphatidate Phosphatase LPIN1, Lipin-1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LPIN1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Researchers should empirically determine the suitability of the Lpin1 lpin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EPFYAAFGNR PADVYSYKQV GVSLNRIFTV NPKGELVQEH AKTNISSYVR LCEVVDHVFP LLKRSHSSDF PCSDTFSNFT FWREPLPPFE NQDIHSASA*. It is sometimes possible for the material contained within the vial of "LPIN1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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