Related Product Information for anti-Lipoteichoic Acid antibody
The monoclonal antibody 55 recognizes lipoteichoic acid (LTA). LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2. Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the cell surface.
Product Categories/Family for anti-Lipoteichoic Acid antibody
References
1. Hogg,S et al; Occurrence of lipotechoic acid in oral streptococci. Int. journal of systematic bacteriology 1997, 47:62. 2. Langevelde, P et al; Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: Quantitative measurements and biological reactivities. Antimicrob Agents Chemother 1998, 42: 3073. 3. Langevelde, P et al; Antibiotic-induced cell wall fragments of Staphylococcus aureus increase endothelial chemokine secretion and adhesiveness for granulocytes. Antimicrob Agents Chemother 1999, 43: 2984. 4. Triantafilou, M et al; Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the golgi are lipid raft-dependent. J Biol Chem 2004, 279: 40882. 5. Henneke, P et al; Role of lipoteichoic acid in the phagocyte response to group B Streptococcus. J Immunol 2005, 174: 6449. 6. Grundling, A et al. Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus. PNAS 2007, 104:8478. 7. Jimenez-Dalmaroni, M et al. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. Plos One 2009, 4:7411. 8. Yajima, A et al. Contribution of phosphoglucosamine mutase to the resistance of Streptococcus gordonii DL1 to polymorphonuclear leukocyte killing. FEMS Microbiol lett 2009, 297: 196. 9. Hashimoto, Y et al. Identification of LTA as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. I.Immunol 2009, 183:7451. 10. Hirose, Y et al. Lipoteichoic acids on lactobacillus platarum cell surfaces correlate with induction of interleukin-12p40 production. Microbiol immunol 2010, 54:143. 11. Wormann, M.E. et al. Enzymatic activities and functional interdependencies of Bacillus subtilis lipoteichoic acid synthesis enzymes. Molecular Microbiology 2011, 79: 566. 12. Palomino, M.M. et al Osmotic stress adaptation in Lactobacillus casei BL23 leads to structural changes in the cell wall polymer lipoteichoic acid. Microbiology 2013, 159:2416. 13. Tadmor, K et al. Listeria Monocytogenes MDR transporters are involved in LTA synthesis and triggering innate immunity during infection. Frontiers in cellular and infection microbiology 2014, 4:16.
Product Notes
The Lipoteichoic Acid (Catalog #
AAA584825) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Lipoteichoic Acid can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin, Immunoassay, Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the Lipoteichoic Acid for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"Lipoteichoic Acid, Monoclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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