Mouse anti-Bovine Lipoprotein Lipase Monoclonal Antibody | anti-LPL antibody

Lipoprotein Lipase antibody

Cat. Num. AAA531173

• Gene Names: LPL; LIPD; HDLCQ11
• Reactivity: Bovine
• Applications: User optimized
• Purity: Protein A affinity chromatography
• Synonyms: Lipoprotein Lipase; Monoclonal Antibody; Lipoprotein Lipase antibody; Monoclonal Lipoprotein Lipase; Anti-Lipoprotein Lipase; anti-LPL antibody

• Host: Mouse
• Reactivity: Bovine
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: Mab-7
• Specificity: Bovine lipoprotein lipase
• Purity/Purification: Protein A affinity chromatography
• Form/Format: Lyophilized. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)
• Sequence Length: 475

• Applicable Applications for anti-LPL antibody: User optimized
• Biological Significance: Lipoprotein lipase is an enzyme that hydrolyzes lipids in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into three free fatty acids and one monoacylglycerol molecule. It requires Apo-CII as a cofactor. Lipoprotein lipase is specifically found in endothelial cells lining the capillaries.
• Cross-Reactivity: Bovine, human
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Immunogen: Lipoprotein lipase antibody was raised in mouse using purified bovine lipoprotein lipase as the immunogen.
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-LPL antibody

Mouse monoclonal Lipoprotein Lipase antibody

Product Categories/Family for anti-LPL antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 4557727
• NCBI GeneID: 4023
• NCBI Accession #: NP_000228.1
• NCBI GenBank Nucleotide #: NM_000237.2
• UniProt Accession #: P06858; Q16282; Q16283; Q96FC4; B2R5T9
• Molecular Weight: 53,162 Da
• NCBI Official Full Name: lipoprotein lipase
• NCBI Official Synonym Full Names: lipoprotein lipase
• NCBI Official Symbol: LPL
• NCBI Official Synonym Symbols: LIPD; HDLCQ11
• NCBI Protein Information: lipoprotein lipase
• UniProt Protein Name: Lipoprotein lipase
• Protein Family: Lipoprotein
• UniProt Gene Name: LPL
• UniProt Synonym Gene Names: LIPD; LPL
• UniProt Entry Name: LIPL_HUMAN

NCBI Description

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]

Uniprot Description

LPL: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Lipid Metabolism - glycerolipid; Membrane protein, GPI anchor; Phospholipase; EC 3.1.1.34

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface; extracellular region; plasma membrane

Molecular Function: heparin binding; triacylglycerol lipase activity; protein binding; lipoprotein lipase activity; apolipoprotein binding; phospholipase activity; triglyceride binding; receptor binding

Biological Process: response to drug; phototransduction, visible light; triacylglycerol metabolic process; phospholipid metabolic process; triacylglycerol catabolic process; lipoprotein metabolic process; triacylglycerol biosynthetic process; response to cold; retinoid metabolic process; fatty acid biosynthetic process

Disease: Hyperlipoproteinemia, Type I; Hyperlipidemia, Familial Combined