Mouse Lipopolysaccharide-induced TNF factor Monoclonal Antibody | anti-LITAF antibody

Mouse Anti Human Lipopolysaccharide-induced TNF factor

Cat. Num. AAA140281

• Gene Names: LITAF; PIG7; SIMPLE; TP53I7
• Applications: ELISA, Western Blot
• Purity: LITAF antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: Lipopolysaccharide-induced TNF factor; Monoclonal Antibody; Mouse Anti Human Lipopolysaccharide-induced TNF factor; LITAF Antibody; Mouse Anti Human; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LPS-induced TNF-alpha factor; p53-induced gene 7 protein; Small integral membrane protein of lysosome/late endosome; LITAF; PIG7; SIMPLE; TP53I7; FLJ38636; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; anti-LITAF antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 heavy chain and kappa light chain
• Clone Number: PAT1F9AT
• Purity/Purification: LITAF antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.; Sterile Filtered clear solution.
• Sequence Length: 161

• Applicable Applications for anti-LITAF antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: LITAF antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:2000 ~ 3000. Recommended starting dilution is 1:2000.
• Immunogen: Anti-human LITAF mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LITAF amino acids 1-161 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-LITAF antibody

Introduction: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. LITAF is a lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of the LITAF gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in the LITAF gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget''s disease (EMPD).

Product Categories/Family for anti-LITAF antibody

Anti-Human CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine

NCBI and Uniprot Product Information

• NCBI GI #: 210147505
• NCBI GeneID: 9516
• NCBI Accession #: NP_001129944.1
• NCBI GenBank Nucleotide #: NM_001136472.1
• Molecular Weight: 15,824 Da
• NCBI Official Full Name: lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
• NCBI Official Synonym Full Names: lipopolysaccharide-induced TNF factor
• NCBI Official Symbol: LITAF
• NCBI Official Synonym Symbols: PIG7; SIMPLE; TP53I7
• NCBI Protein Information: lipopolysaccharide-induced tumor necrosis factor-alpha factor; LPS-induced TNF-alpha factor; lipopolysaccharide-induced TNF-alpha factor; p53-induced gene 7 protein; small integral membrane protein of lysosome/late endosome; tumor protein p53 inducible protein 7
• UniProt Protein Name: Lipopolysaccharide-induced tumor necrosis factor-alpha factor
• Protein Family: Lipopolysaccharide-induced tumor necrosis factor-alpha factor
• UniProt Gene Name: LITAF
• UniProt Synonym Gene Names: PIG7; SIMPLE; LPS-induced TNF-alpha factor
• UniProt Entry Name: LITAF_HUMAN

NCBI Description

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

LITAF: Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; plasma membrane

Molecular Function: signal transducer activity; protein binding; WW domain binding

Biological Process: regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; negative regulation of NF-kappaB import into nucleus; signal transduction; regulation of cytokine production; aging

Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1c