Mouse anti-Human LIM Homeobox Protein 1 Monoclonal Antibody | anti-LHX1 antibody

LIM Homeobox Protein 1 (LIM/homeobox Protein Lhx1, Homeobox Protein 1, hLim-1, LHX1, LIM-1, LIM1)

Cat. Num. AAA609665

• Gene Names: LHX1; LIM1; LIM-1; MGC126723; MGC138141
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: LIM Homeobox Protein 1; Monoclonal Antibody; LIM Homeobox Protein 1 (LIM/homeobox Protein Lhx1; Homeobox Protein 1; hLim-1; LHX1; LIM-1; LIM1); Anti -LIM Homeobox Protein 1 (LIM/homeobox Protein Lhx1; anti-LHX1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G376
• Specificity: Recognizes human LIM homeobox protein 1.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH7.2. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-LHX1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and direct ELISA.
• Immunogen: Partial recombinant protein of human LIM homeobox protein 1 (aa1-101) with a GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-LHX1 antibody

LIM homeobox protein 1 is a potential transcription factor that may play a role in differentiation and development of neural and lymphoid cells. It contains 1 homeobox DNA-binding domain and 2 LIM zinc-binding domains. The latter have a negative regulatory function and disruption of the LIM domains results in an avtivated form. It localises to the nucleus and is expressed in the brain, thymus and tonsils. It is also expressed in smaples from patients with chronic myeloid leukemia and in 58% of acute myeloid leukemia cell lines.

Product Categories/Family for anti-LHX1 antibody

Antibodies; Abs to Transcription Factors; Homeobox (HOX)

NCBI and Uniprot Product Information

• NCBI GI #: 30410785
• NCBI GeneID: 3975
• NCBI Accession #: NP_005559.2
• NCBI GenBank Nucleotide #: NM_005568.3
• UniProt Accession #: P48742; Q3MIW0; Q58F18
• Molecular Weight: 44,808 Da
• NCBI Official Full Name: LIM/homeobox protein Lhx1
• NCBI Official Synonym Full Names: LIM homeobox 1
• NCBI Official Symbol: LHX1
• NCBI Official Synonym Symbols: LIM1; LIM-1; MGC126723; MGC138141
• NCBI Protein Information: LIM/homeobox protein Lhx1; OTTHUMP00000164082; LIM homeobox protein 1; homeobox protein Lim-1
• UniProt Protein Name: LIM/homeobox protein Lhx1
• UniProt Gene Name: LHX1
• UniProt Synonym Gene Names: LIM-1; LIM1
• UniProt Entry Name: LHX1_HUMAN

NCBI Description

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq]

Uniprot Description

LHX1: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.

Protein type: Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: protein complex; nucleus

Molecular Function: zinc ion binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; motor axon guidance; forebrain regionalization; embryonic pattern specification; uterus development; pronephros development; post-embryonic development; anterior/posterior pattern formation; cell-cell signaling; ectoderm formation; ureteric bud development; anatomical structure formation; cerebellum development; kidney development; fallopian tube development; cervix development; nervous system development; anatomical structure morphogenesis; vagina development; ventral spinal cord development; gastrulation with mouth forming second; embryonic viscerocranium morphogenesis; somite rostral/caudal axis specification; pattern specification process; Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; organ morphogenesis; telencephalon development; positive regulation of embryonic development; dorsal/ventral pattern formation; ureteric bud branching; endoderm formation; regulation of gene expression; embryonic retina morphogenesis in camera-type eye; cerebellar Purkinje cell differentiation; spinal cord association neuron differentiation; negative regulation of transcription, DNA-dependent; urogenital system development; anterior/posterior axis specification