Testing Data
(Profile of anti-LDLR reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block' purified anti-CD16/CD32 mAb 2.4G2 prior to staining, washed, then stained with PerCP Rabbit anti-LDLR.)
Rabbit anti-Mouse LDLR/LDL Receptor Monoclonal Antibody | anti-LDLR antibody
Recombinant Anti-LDLR/LDL Receptor Antibody (PerCP), Rabbit Monoclonal
Testing Data
(Profile of anti-LDLR reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block' purified anti-CD16/CD32 mAb 2.4G2 prior to staining, washed, then stained with PerCP Rabbit anti-LDLR.)
Testing Data
(Profile of anti-LDLR reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block' purified anti-CD16/CD32 mAb 2.4G2 prior to staining, washed, then stained with PerCP Rabbit anti-LDLR.)
NCBI and Uniprot Product Information
Uniprot Description
LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Cell surface; Membrane protein, integral
Cellular Component: apical part of cell; basolateral plasma membrane; caveola; cell surface; coated pit; early endosome; endosome; external side of plasma membrane; Golgi apparatus; late endosome; lysosome; membrane; plasma membrane; receptor complex; recycling endosome membrane
Molecular Function: glycoprotein binding; identical protein binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protease binding; protein binding; very-low-density lipoprotein receptor activity
Biological Process: cholesterol absorption; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endocytosis; lipid metabolic process; lipoprotein catabolic process; lipoprotein metabolic process; phospholipid transport; positive regulation of inflammatory response
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Product Notes
The LDLR ldlr (Catalog #AAA8111350) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-LDLR/LDL Receptor Antibody (PerCP), Rabbit Monoclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LDLR/LDL Receptor can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS/FCM). Researchers should empirically determine the suitability of the LDLR ldlr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LDLR/LDL Receptor, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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