Western Blot (WB)
(Western Blot analysis of Rat Brain Membrane showing detection of LAR protein using Mouse Anti-LAR Monoclonal Antibody, Clone S165-38. Primary Antibody: Mouse Anti-LAR Monoclonal Antibody at 1:250.)
Mouse LAR/PTPRF Monoclonal Antibody | anti-PTPRF antibody
LAR/PTPRF Antibody: FITC
Western Blot (WB)
(Western Blot analysis of Rat Brain Membrane showing detection of LAR protein using Mouse Anti-LAR Monoclonal Antibody, Clone S165-38. Primary Antibody: Mouse Anti-LAR Monoclonal Antibody at 1:250.)
Western Blot (WB)
(Western Blot analysis of Rat Brain Membrane showing detection of LAR protein using Mouse Anti-LAR Monoclonal Antibody, Clone S165-38. Primary Antibody: Mouse Anti-LAR Monoclonal Antibody at 1:250.)
Scientific Background: PTPRF or leukocyte common antigen-related protein (LAR) is a widely expressed protein tyrosine phosphatase with an extracellular receptor region that resembles a cell adhesion molecule. PTPRF removes phosphate group from beta-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function (1,2,3,4). Anti-PTPRF (C-terminal) antibody is specific for the extracellular and cytoplasmic subunits of human PTPRF (approx. 210, 150 and 85 kDa). Detection of the PTPRF bands by immunoblotting is specifically inhibited by the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
PTPRF: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: integral to plasma membrane
Molecular Function: heparin binding; transmembrane receptor protein tyrosine phosphatase activity; protein complex binding; protein tyrosine phosphatase activity
Biological Process: cell migration; cell adhesion; transmembrane receptor protein tyrosine phosphatase signaling pathway
Disease: Breasts And/or Nipples, Aplasia Or Hypoplasia Of, 2
Research Articles on PTPRF
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Product Notes
The PTPRF ptprf (Catalog #AAA800828) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The LAR/PTPRF Antibody: FITC reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LAR/PTPRF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). 1:1000 WB. Researchers should empirically determine the suitability of the PTPRF ptprf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAR/PTPRF, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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