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Mouse anti-Human Laminin B1 Monoclonal Antibody | anti-LAMB1 antibody

Laminin B1 antibody

Gene Names
LAMB1; CLM; LIS5
Reactivity
Human
Applications
ELISA, Western Blot, Immunofluorescence, Immunoprecipitation
Synonyms
Laminin B1; Monoclonal Antibody; Laminin B1 antibody; Monoclonal Laminin B1; Anti-Laminin B1; Laminin subunit beta 1; Anti Laminin B1; Laminin alpha 1; Laminin A chain; LAMB1; Laminin B1 chain; Laminin alpha 1 chain; LAMA1; anti-LAMB1 antibody
Ordering
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 kappa
Specificity
Human
Form/Format
Supplied in ascites fluid
Sequence Length
1786
Applicable Applications for anti-LAMB1 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
Biological Significance
Laminins are major proteins in the basal lamina a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, adhesion as well as phenotype and survival. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma. The beta 1 chain has 7 structurally distinct domains, which it shares with other beta chain isomers.
Immunogen
Laminin B1 antibody was raised in mouse using purified human laminin as the immunogen.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
Related Product Information for anti-LAMB1 antibody
Mouse monoclonal Laminin B1 antibody
Product Categories/Family for anti-LAMB1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
198,038 Da
NCBI Official Full Name
laminin B1
NCBI Official Synonym Full Names
laminin, beta 1
NCBI Official Symbol
LAMB1
NCBI Official Synonym Symbols
CLM; LIS5
NCBI Protein Information
laminin subunit beta-1
UniProt Protein Name
Laminin subunit beta-1
Protein Family
UniProt Gene Name
LAMB1
UniProt Entry Name
LAMB1_HUMAN

NCBI Description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

Uniprot Description

LAMB1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: extracellular matrix; extracellular space; laminin-8 complex; laminin-1 complex; laminin-2 complex; perinuclear region of cytoplasm; laminin-10 complex; extracellular region; basement membrane

Molecular Function: integrin binding; enzyme binding; extracellular matrix structural constituent; structural molecule activity; glycosphingolipid binding

Biological Process: odontogenesis; axon guidance; extracellular matrix disassembly; extracellular matrix organization and biogenesis; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; negative regulation of cell adhesion; cell adhesion; neurite development; positive regulation of epithelial cell proliferation; embryo implantation; positive regulation of cell migration

Disease: Lissencephaly 5

Research Articles on LAMB1

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Product Notes

The LAMB1 lamb1 (Catalog #AAA531617) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Laminin B1 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Laminin B1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the LAMB1 lamb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Laminin B1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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