Mouse anti-Human Ki67 Monoclonal Antibody | anti-Ki67 antibody

Ki67

Cat. Num. AAA556104

• Gene Names: MKI67; KIA
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Ki67; Monoclonal Antibody; anti-Ki67 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG
• Form/Format: Affinity Purified antibody; Liquid with PBS buffer, pH7.4 with 0.02% Sodium Azide

• Applicable Applications for anti-Ki67 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:1,000-3,000; WB: 1:500-1,000
• Immunogen: Recombinant Human Ki67
• Preparation and Storage: The product can be stored undiluted for several weeks at 4 degree C. Dilute only immediately before use. Aliquot and store at -20 degree C for long term. Avoid freeze thaw-cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry staining of MO47005 on human cervix tissue.)

Immunohistochemistry (IHC)

(Immunohistochemistry staining of MO47005 on human tonsil tissue.)

Related Product Information for anti-Ki67 antibody

Ki67 Antibody can be used to detect the presence, absence, or level of expression of Ki67. As a nuclear, non-histone protein that is expressed only during active phases of the cell cycle (G1, S, G2 and M), but not in the resting phases (G0 and G1 early phase); Ki67 is linked to cell proliferation. It is used as a marker to grade tumor proliferation rates.

NCBI and Uniprot Product Information

• NCBI GI #: 225543215
• NCBI GeneID: 4288
• NCBI Accession #: NP_001139438.1
• NCBI GenBank Nucleotide #: NM_001145966.1
• UniProt Accession #: P46013; Q5VWH2
• Molecular Weight: 358,694 Da
• NCBI Official Full Name: antigen KI-67 isoform 2
• NCBI Official Synonym Full Names: antigen identified by monoclonal antibody Ki-67
• NCBI Official Symbol: MKI67
• NCBI Official Synonym Symbols: KIA
• NCBI Protein Information: antigen KI-67; proliferation-related Ki-67 antigen
• UniProt Protein Name: Antigen KI-67
• UniProt Gene Name: MKI67
• UniProt Entry Name: KI67_HUMAN

NCBI Description

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

Uniprot Description

KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: membrane; cytoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein binding; ATP binding

Biological Process: cell proliferation; meiosis