Mouse KCNQ4 Monoclonal Antibody | anti-Kcnq4 antibody

KCNQ4 (KCNQ 4, DFNA2, KQT-like 4, Kv7.4, Potassium Channel KQT-like 4, Potassium Channel Subunit alpha KvLQT4, Potassium Voltage Gated Channel KQT-like Protein 4, Potassium Voltage Gated Channel KQT-like Subfamily Member 4, Potassium Voltage Gated Channel

Cat. Num. AAA607391

• Gene Names: Kcnq4; Kcnq4
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: KCNQ4; Monoclonal Antibody; KCNQ4 (KCNQ 4; DFNA2; KQT-like 4; Kv7.4; Potassium Channel KQT-like 4; Potassium Channel Subunit alpha KvLQT4; Potassium Voltage Gated Channel KQT-like Protein 4; Potassium Voltage Gated Channel KQT-like Subfamily Member 4; Potassium Voltage Gated Channel; Anti -KCNQ4 (KCNQ 4; anti-Kcnq4 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10F743
• Specificity: Recognizes human KCNQ4. Species Crossreactivity: rat.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.

• Applicable Applications for anti-Kcnq4 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry.; Dilution: Western Blot: 1-10ug/ml; Immunocytochemistry: 0.1-1ug/m
• Immunogen: Fusion protein amino acid 2-77 of human KCNQ4 (Kv7.4, KvLQT4, accession number P56696).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Kcnq4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or

Product Categories/Family for anti-Kcnq4 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 7671228
• NCBI GeneID: 298496
• UniProt Accession #: Q9JK96
• Molecular Weight: 18,845 Da
• NCBI Official Full Name: KCNQ4
• NCBI Official Synonym Full Names: potassium voltage-gated channel, KQT-like subfamily, member 4
• NCBI Official Symbol: Kcnq4
• NCBI Official Synonym Symbols: Kcnq4
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; potassium channel subunit alpha KvLQT4; voltage-gated potassium channel subunit Kv7.4; potassium voltage-gated channel, subfamily Q, member 4
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 4
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: Kcnq4
• UniProt Entry Name: KCNQ4_RAT

NCBI Description

mutations in the human gene causes autosomal dominant, non-syndromic, progressive hearing loss [RGD]

Uniprot Description

KCNQ4: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors. Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A). DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: voltage-gated potassium channel complex; neuron projection; cytoplasm; plasma membrane; basal plasma membrane

Molecular Function: voltage-gated potassium channel activity; potassium channel activity

Biological Process: inner ear morphogenesis; sensory perception of sound; negative regulation of synaptic transmission, dopaminergic; potassium ion transport