Testing Data
(Inhibition of angiogenesis on the chick chorioallantoic membrane by MBS601612.)
Mouse Integrin alphaV, beta3 Monoclonal Antibody | anti-ITGB3 antibody
Integrin alphaV, beta3
Gene Names
ITGB3; CD61
Reactivity
Avian, Bovine, Canine, Chicken, Human, Monkey, Porcine, Rabbit
Applications
Immunoprecipitation, Immunohistochemistry, Immunofluorescence
Purity
Affinity PurifiedPurified by Protein A Sepharose chromatography
Synonyms
Integrin alphaV; beta3; Monoclonal Antibody; Anti -Integrin alphaV; anti-ITGB3 antibody
Host
Mouse
Reactivity
Avian, Bovine, Canine, Chicken, Human, Monkey, Porcine, Rabbit
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q880
Specificity
Recognizes human vitronectin receptor aVb3 complex, an RGD-directed adhesion receptor. Species Crossreactivity: bovine, chick, monkey, porcine, canine, rabbit and avian. Not reactive with rat tissue.
Purity/Purification
Affinity Purified
Purified by Protein A Sepharose chromatography
Purified by Protein A Sepharose chromatography
Form/Format
Supplied as a liquid in 0.02M PBS, pH 7.6, 0.1% sodium azide.
Applicable Applications for anti-ITGB3 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
Suitable for use in Immunoprecipitation, Immunoflourescence, Immunohistochemistry and Inhibition. Not effective for immunohistochemical staining of paraffin-embedded tissue sections.
Dilution: Immunohistochemistry/Immunofluorescence: 10ug/ml for staining of bFGF-treated 6um cryosections of chick chorioallantoic membrane fixed with acetone.
Inhibition: 10-25ug/ml adheres cells to vitronectin coated surfaces.
Dilution: Immunohistochemistry/Immunofluorescence: 10ug/ml for staining of bFGF-treated 6um cryosections of chick chorioallantoic membrane fixed with acetone.
Inhibition: 10-25ug/ml adheres cells to vitronectin coated surfaces.
Immunogen
Integrin alphaV, beta3 from human placenta.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Testing Data
(Inhibition of angiogenesis on the chick chorioallantoic membrane by MBS601612.)
Testing Data
(Inhibition of angiogenesis on the chick chorioallantoic membrane by MBS601612.)
Related Product Information for anti-ITGB3 antibody
The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. (Cancer and Metastasis Reviews 1991. 10:3). Due to its involvement in angiogenesis, the integrin aVb3 receptor is one of the most intensely studied of the integrin receptors.
Product Categories/Family for anti-ITGB3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
integrin beta-3
NCBI Official Symbol
ITGB3
NCBI Official Synonym Symbols
CD61
NCBI Protein Information
integrin beta-3; beta3 integrin; integrin beta 3; glycoprotein GPIIIa
Protein Family
Research Articles on ITGB3
Similar Products
Product Notes
The ITGB3 (Catalog #AAA601612) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Integrin alphaV, beta3 reacts with Avian, Bovine, Canine, Chicken, Human, Monkey, Porcine, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin alphaV, beta3 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in Immunoprecipitation, Immunoflourescence, Immunohistochemistry and Inhibition. Not effective for immunohistochemical staining of paraffin-embedded tissue sections. Dilution: Immunohistochemistry/Immunofluorescence: 10ug/ml for staining of bFGF-treated 6um cryosections of chick chorioallantoic membrane fixed with acetone. Inhibition: 10-25ug/ml adheres cells to vitronectin coated surfaces. Researchers should empirically determine the suitability of the ITGB3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin alphaV, beta3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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