Mouse anti-Human IL1RAPL1 Monoclonal Antibody | anti-IL1RAPL1 antibody

Anti-IL1RAPL1 Antibody, Mouse Monoclonal

Cat. Num. AAA8101522

• Gene Names: IL1RAPL1; IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: IL1RAPL1; Monoclonal Antibody; Anti-IL1RAPL1 Antibody; Mouse Monoclonal; IL-1R8/IL1RAPL1 Antibody; Mouse MAb; interleukin 1 receptor accessory protein-like 1; Anti-IL1R8 Antibody; Anti-IL1RAPL Antibody; Anti-MRX10 Antibody; Anti-MRX21 Antibody; Anti-MRX34 Antibody; Anti-OPHN4 Antibody; Anti-TIGIRR-2 Antibody; anti-IL1RAPL1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 2E10E1F5
• Specificity: Human IL-1R8/IL1RAPL1.; No cross-reactivity in ELISA with Human IL18R1, Human IL1R1, Human IL1R2, Human SIGIRR, Human IL1R4, Human IL1R7, Human IL1RA, Human cell lysate (293 cell line)
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IL1RAPL1 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human IL-1R8/IL1RAPL1 protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1R8/IL1RAPL1 (rh IL-1R8/IL1RAPL1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IL1RAPL1 antibody

Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of the interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signaling via the NFkB pathway. The means of signaling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect the human cognitive ability to some extent, especially the memory and concentration capability.

References

Frdric Gambino, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci. 104 (21): 9063-8.Wheway JM, et al. (2003) A complex deletion-inversion-deletion event results in a chimeric IL1RAPL1-dystrophin transcript and a contiguous gene deletion syndrome. J Med Genet. 40: 127-131.

NCBI and Uniprot Product Information

• NCBI GI #: 7657232
• NCBI GeneID: 11141
• NCBI Accession #: NP_055086.1
• NCBI GenBank Nucleotide #: NM_014271.3
• UniProt Accession #: Q9NZN1; Q9UJ53; A0AVG4
• Molecular Weight: 79,969 Da
• NCBI Official Full Name: interleukin-1 receptor accessory protein-like 1
• NCBI Official Synonym Full Names: interleukin 1 receptor accessory protein like 1
• NCBI Official Symbol: IL1RAPL1
• NCBI Official Synonym Symbols: IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1
• NCBI Protein Information: interleukin-1 receptor accessory protein-like 1
• UniProt Protein Name: Interleukin-1 receptor accessory protein-like 1
• Protein Family: Interleukin-1 receptor accessory protein
• UniProt Gene Name: IL1RAPL1
• UniProt Synonym Gene Names: OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2
• UniProt Entry Name: IRPL1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]

Uniprot Description

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp22.1-p21.3

Cellular Component: postsynaptic membrane; cell surface; axon; cytoplasm; dendrite; plasma membrane; integral to membrane

Molecular Function: voltage-gated calcium channel activity; protein binding; interleukin-1 binding; receptor binding

Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction

Disease: Mental Retardation, X-linked 21