IL-1R8 / IL1RAPL1 recombinant protein

Recombinant Human IL-1R8 / IL1RAPL1 Protein (Fc tag)

Cat. Num. AAA2546448

• Gene Names: IL1RAPL1; IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2
• Purity: > 95 % as determined by SDS-PAGE
• Synonyms: IL-1R8 / IL1RAPL1; Recombinant Human IL-1R8 / IL1RAPL1 Protein (Fc tag); IL1RAPL1; IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2; IL-1R8 / IL1RAPL1 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 696

• Application Notes: The recombinant human IL1R8/Fc is a disulfide-linked homodimer. The reduced monomer consists of 574 amino acids and has a predicted molecular mass of 65 kDa. As a result of glycosylation, the rh IL1R8/Fc monomer migrates with an apparent molecular mass of 80-85 kDa in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Leu 19
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for IL-1R8 / IL1RAPL1 recombinant protein

Background: Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.

Description: A DNA sequence encoding the human IL1R8 (NP_055086.1) extracellular domain (Met 1-Leu 354) was fused with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 7657232
• NCBI GeneID: 11141
• NCBI Accession #: NP_055086.1
• NCBI GenBank Nucleotide #: NM_014271.3
• UniProt Accession #: Q9NZN1; Q9UJ53; A0AVG4
• Molecular Weight: 79,969 Da
• NCBI Official Full Name: interleukin-1 receptor accessory protein-like 1
• NCBI Official Synonym Full Names: interleukin 1 receptor accessory protein like 1
• NCBI Official Symbol: IL1RAPL1
• NCBI Official Synonym Symbols: IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2
• NCBI Protein Information: interleukin-1 receptor accessory protein-like 1
• UniProt Protein Name: Interleukin-1 receptor accessory protein-like 1
• UniProt Gene Name: IL1RAPL1
• UniProt Synonym Gene Names: OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2

NCBI Description

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]

Uniprot Description

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp21.3-p21.2

Cellular Component: cell surface; dendrite; plasma membrane

Molecular Function: interleukin-1 binding; protein binding; receptor binding; voltage-gated calcium channel activity

Biological Process: heterophilic cell adhesion; negative regulation of exocytosis; neuron differentiation; positive regulation of dendrite morphogenesis

Disease: Mental Retardation, X-linked 21