Mouse anti-Rat IL1R1 Monoclonal Antibody | anti-IL1R1 antibody
Anti-IL1R1 Antibody, Mouse Monoclonal
Reactivity
Rat
Applications
ELISA
Purity
Protein A
Synonyms
IL1R1; Monoclonal Antibody; Anti-IL1R1 Antibody; Mouse Monoclonal; IL1R1/IL-1R1/IL-1 RI Antibody; Mouse MAb; interleukin 1 receptor; type I; anti-IL1R1 antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Clone Number
10
Specificity
Rat IL1R1/IL-1R1/IL-1 RI
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-IL1R1 antibody
ELISA (EIA) (Cap)
Application Notes
ELISA (Cap): This antibody will detect Rat IL1R1/IL-1R1/IL-1 RI in ELISA pair set.
In a sandwich ELISA, it can be used as capture antibody when paired with.
In a sandwich ELISA, it can be used as capture antibody when paired with.
Immunogen
Recombinant Rat IL1R1/IL-1R1/IL-1 RI Protein
Conjugation
Unconjugated
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL1R1/IL-1R1/IL-1 RI (rR IL1R1/IL-1R1/IL-1 RI). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-IL1R1 antibody
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1beta activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1beta induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
Product Categories/Family for anti-IL1R1 antibody
References
Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66,759 Da
NCBI Official Full Name
interleukin-1 receptor type 1
NCBI Official Synonym Full Names
interleukin 1 receptor, type I
NCBI Official Symbol
Il1r1
NCBI Protein Information
interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 beta receptor type 1 soluble form; interleukin 1 bete receptor type
Protein Family
NCBI Description
receptor for interleukin-1; involved in inflammatory response signalling [RGD, Feb 2006]
Research Articles on IL1R1
Similar Products
Product Notes
The IL1R1 (Catalog #AAA8112651) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL1R1 Antibody, Mouse Monoclonal reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IL1R1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA) (Cap). ELISA (Cap): This antibody will detect Rat IL1R1/IL-1R1/IL-1 RI in ELISA pair set. In a sandwich ELISA, it can be used as capture antibody when paired with. Researchers should empirically determine the suitability of the IL1R1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1R1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
