IL-18 recombinant antibody
Anti-IL-18 [125-2H]
Gene Names
IL18; IGIF; IL-18; IL-1g; IL1F4
Reactivity
Human
Applications
ELISA, Immunofluorescence, Immunoprecipitation, Neutralization Assay
Purity
Protein A Affinity Purified
Synonyms
IL-18; Monoclonal Recombinant Antibody; Anti-IL-18 [125-2H]; Iboctadekin; Interleukin 18 (Interferon-gamma-inducing factor); IGIF; IL1F4; IL-1g; IL-18 recombinant antibody
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1, Kappa
Clone Number
125-2H
Specificity
Recognizes the active form of human IL-18.
Purity/Purification
Protein A Affinity Purified
Concentration
1 mg/ml (varies by lot)
Sequence Length
189
Applicable Applications for IL-18 recombinant antibody
ELISA (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Neutralization
Immunogen
Fusion of splenocytes from mice immunized with human IL-18, with SP2/O mouse myeloma cells.
Buffer Composition
PBS only with 0.02% Proclin 300.
Labeled Substance
None
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Related Product Information for IL-18 recombinant antibody
Recombinant monoclonal antibody to IL-18. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 125-2H.
Fusion of splenocytes from mice immunized with human IL-18, with SP2/O mouse myeloma cells.
Fusion of splenocytes from mice immunized with human IL-18, with SP2/O mouse myeloma cells.
Product Categories/Family for IL-18 recombinant antibody
References
Taniguchi M, Nagaoka K, Kunikata T, Kayano T, Yamauchi H, Nakamura S, Ikeda M, Orita K, Kurimoto M. Characterization of anti-human interleukin-18 (IL-18)/interferon-gammainducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA. J Immunol Methods. 1997 Aug 7; 206(1-2):107-13. PMID:9328573
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,896 Da
NCBI Official Full Name
interleukin-18 isoform 2
NCBI Official Synonym Full Names
interleukin 18
NCBI Official Symbol
IL18
NCBI Official Synonym Symbols
IGIF; IL-18; IL-1g; IL1F4
NCBI Protein Information
interleukin-18
UniProt Protein Name
Interleukin-18
UniProt Gene Name
IL18
UniProt Synonym Gene Names
IL-183 PublicationsManual assertion based on opinion iniRef.13; IFN-gamma-inducing factor2 PublicationsManual assertion based on opinion iniRef.13; IL-1 gamma
NCBI Description
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Description
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
Research Articles on IL-18
Similar Products
Product Notes
The IL-18 il18 (Catalog #AAA488289) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL-18 [125-2H] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-18 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Neutralization. Researchers should empirically determine the suitability of the IL-18 il18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-18, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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