Mouse IL-10 Monoclonal Antibody | anti-IL-10 antibody
mAb anti-Human IL-10
Western blot: The anti-human IL-10 antibody clone 6D2 reacts with recombinant human IL-10 (Immunogen).
background: IL-10 is expressed by a variety of cells and plays an important role in inflammatory and immune responses. The biological activities of IL-10 include both immunosuppressive and immuno-stimulatory effects. It suppresses the production of pro-inflammatory cytokines by monocytes and neutrophils, and down-regulates the expression of activating and co-stimulatory molecules on monocytes and dendritic cells. It stimulates the growth of B cells and mast cells, and inhibits or enhances the activities of T cells depending on their activation conditions. Human IL-10 is a protein with 160 amino acids.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Uniprot Description
IL10: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family.
Protein type: Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 1q31-q32
Cellular Component: extracellular space
Molecular Function: growth factor activity; cytokine activity; interleukin-10 receptor binding
Biological Process: B cell proliferation; regulation of isotype switching; negative regulation of chronic inflammatory response to antigenic stimulus; leukocyte chemotaxis; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; positive regulation of JAK-STAT cascade; negative regulation of B cell proliferation; negative regulation of membrane protein ectodomain proteolysis; response to insulin stimulus; negative regulation of interferon-alpha biosynthetic process; cytoplasmic sequestering of NF-kappaB; negative regulation of T cell proliferation; cell-cell signaling; response to molecule of bacterial origin; positive regulation of MHC class II biosynthetic process; negative regulation of interferon-gamma production; negative regulation of interleukin-6 production; hemopoiesis; negative regulation of tumor necrosis factor biosynthetic process; inflammatory response; aging; response to drug; response to inactivity; negative regulation of interleukin-12 production; positive regulation of B cell apoptosis; T-helper 2 type immune response; negative regulation of myeloid dendritic cell activation; negative regulation of nitric oxide biosynthetic process; negative regulation of cytokine secretion during immune response; regulation of gene expression; B cell differentiation; defense response to bacterium; negative regulation of MHC class II biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; receptor biosynthetic process; response to activity; positive regulation of cytokine secretion; negative regulation of apoptosis
Disease: Graft-versus-host Disease, Susceptibility To; Rheumatoid Arthritis; Human Immunodeficiency Virus Type 1, Susceptibility To
Research Articles on IL-10
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Product Notes
The IL-10 il10 (Catalog #AAA592381) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The mAb anti-Human IL-10 reacts with Human. Others not tested and may cross-react with other species as described in the data sheet. AAA Biotech's IL-10 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Indirect ELISA: The anti-human IL-10 antibody clone 6D2 reacts with recombinant human IL-10. Western blot: The anti-human IL-10 antibody clone 6D2 reacts with recombinant human IL-10 (Immunogen). Researchers should empirically determine the suitability of the IL-10 il10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-10, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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