Rabbit anti-Human IFNB1 Monoclonal Antibody | anti-IFNB1 antibody
Rabbit anti Human IFNB1 Monoclonal Antibody
Gene Names
Ifnb1; Ifb; IFNB; IFN-beta
Reactivity
Human
Applications
ELISA
Synonyms
IFNB1 ; Monoclonal Antibody; Rabbit anti Human IFNB1 Monoclonal Antibody; anti-IFNB1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Sequence Length
182
Applicable Applications for anti-IFNB1 antibody
ELISA (EIA)
Application Notes
ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IFNbeta. The detection limit for Human IFNbeta is approximately 0.00975 ng/well.
Immunogen
Recombinant Human IFN beta protein
Buffer
0.2 mum filtered solution in PBS with 5% trehalose
Preparation and Storage
This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-IFNB1 antibody
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or cause autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of a chronic progressive CNS inflammation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
22,127 Da
NCBI Official Full Name
interferon beta
NCBI Official Synonym Full Names
interferon beta 1, fibroblast
NCBI Official Symbol
Ifnb1
NCBI Official Synonym Symbols
Ifb; IFNB; IFN-beta
NCBI Protein Information
interferon beta
UniProt Protein Name
Interferon beta
UniProt Gene Name
Ifnb1
UniProt Synonym Gene Names
Ifb; Ifnb; IFN-beta
UniProt Entry Name
IFNB_MOUSE
Uniprot Description
IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space
Molecular Function: chloramphenicol O-acetyltransferase activity; cytokine activity; interferon-alpha/beta receptor binding
Biological Process: adaptive immune response; B cell activation during immune response; B cell differentiation; B cell proliferation; cytokine and chemokine mediated signaling pathway; defense response to bacterium; defense response to virus; humoral immune response; innate immune response; natural killer cell activation during immune response; negative regulation of T cell differentiation; negative regulation of viral genome replication; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; T cell activation during immune response
Research Articles on IFNB1
Similar Products
Product Notes
The IFNB1 ifnb1 (Catalog #AAA2544055) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human IFNB1 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IFNB1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IFNbeta. The detection limit for Human IFNbeta is approximately 0.00975 ng/well. Researchers should empirically determine the suitability of the IFNB1 ifnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFNB1 , Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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